Literature DB >> 12639985

The challenge of molecular medicine: complexity versus Occam's razor.

Eric A Sobie1, Silvia Guatimosim, Long-Sheng Song, W J Lederer.   

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Year:  2003        PMID： 12639985      PMCID： PMC153775          DOI： 10.1172/JCI18153

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


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  20 in total

1.  Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts. Role of phosphatases and response to isoproterenol.

Authors:  Steven Reiken; Marta Gaburjakova; Silvia Guatimosim; Ana M Gomez; Jeanine D'Armiento; Daniel Burkhoff; Jie Wang; Guy Vassort; W Jonathan Lederer; Andrew R Marks
Journal:  J Biol Chem       Date:  2002-10-24       Impact factor: 5.157

2.  PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

Authors:  S O Marx; S Reiken; Y Hisamatsu; T Jayaraman; D Burkhoff; N Rosemblit; A R Marks
Journal:  Cell       Date:  2000-05-12       Impact factor: 41.582

3.  Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase.

Authors:  U Schmidt; F del Monte; M I Miyamoto; T Matsui; J K Gwathmey; A Rosenzweig; R J Hajjar
Journal:  Circulation       Date:  2000-02-22       Impact factor: 29.690

4.  Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice.

Authors:  B K McConnell; K A Jones; D Fatkin; L H Arroyo; R T Lee; O Aristizabal; D H Turnbull; D Georgakopoulos; D Kass; M Bond; H Niimura; F J Schoen; D Conner; D A Fischman; C E Seidman; J G Seidman; D H Fischman
Journal:  J Clin Invest       Date:  1999-11       Impact factor: 14.808

5.  Arrhythmogenesis and contractile dysfunction in heart failure: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness.

Authors:  S M Pogwizd; K Schlotthauer; L Li; W Yuan; D M Bers
Journal:  Circ Res       Date:  2001-06-08       Impact factor: 17.367

6.  Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.

Authors:  S Minamisawa; M Hoshijima; G Chu; C A Ward; K Frank; Y Gu; M E Martone; Y Wang; J Ross; E G Kranias; W R Giles; K R Chien
Journal:  Cell       Date:  1999-10-29       Impact factor: 41.582

7.  Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure.

Authors:  F del Monte; E Williams; D Lebeche; U Schmidt; A Rosenzweig; J K Gwathmey; E D Lewandowski; R J Hajjar
Journal:  Circulation       Date:  2001-09-18       Impact factor: 29.690

8.  Targeting phospholamban by gene transfer in human heart failure.

Authors:  Federica del Monte; Sian E Harding; G William Dec; Judith K Gwathmey; Roger J Hajjar
Journal:  Circulation       Date:  2002-02-26       Impact factor: 29.690

9.  Cellular and functional defects in a mouse model of heart failure.

Authors:  G Esposito; L F Santana; K Dilly; J D Cruz; L Mao; W J Lederer; H A Rockman
Journal:  Am J Physiol Heart Circ Physiol       Date:  2000-12       Impact factor: 4.733

10.  Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.

Authors:  H A Rockman; K R Chien; D J Choi; G Iaccarino; J J Hunter; J Ross; R J Lefkowitz; W J Koch
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205
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  4 in total

1.  Return of calcium: manipulating intracellular calcium to prevent cardiac pathologies.

Authors:  Yibin Wang; Joshua I Goldhaber
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-12       Impact factor: 11.205

2.  Orphaned ryanodine receptors in the failing heart.

Authors:  Long-Sheng Song; Eric A Sobie; Stacey McCulle; W J Lederer; C William Balke; Heping Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-06       Impact factor: 11.205

Review 3.  Remodeling of calcium handling in human heart failure.

Authors:  Qing Lou; Ajit Janardhan; Igor R Efimov
Journal:  Adv Exp Med Biol       Date:  2012       Impact factor: 2.622

4.  A novel information retrieval model for high-throughput molecular medicine modalities.

Authors:  Firas H Wehbe; Steven H Brown; Pierre P Massion; Cynthia S Gadd; Daniel R Masys; Constantin F Aliferis
Journal:  Cancer Inform       Date:  2009-02-09
  4 in total

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