| Literature DB >> 12639575 |
Ramdas Vidya1, MariJean Eggen, Gunda I Georg, Richard H Himes.
Abstract
An efficient synthesis of a C16 side chain benzophenone analogue of cryptophycin-24 using a crotylboration reaction and Heck coupling as key steps is described. In an in vitro tubulin assembly assay, the benzophenone analogue of the beta isomer (IC(50)=7.4 microM) is twice as active as cryptophycin-24 (IC(50)=15 microM).Entities:
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Year: 2003 PMID： 12639575 DOI： 10.1016/s0960-894x(02)01023-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823