| Literature DB >> 12639560 |
Neil R Curtis1, Helen J Diggle, Janusz J Kulagowski, Clare London, Sarah Grimwood, Peter H Hutson, Fraser Murray, Pawel Richards, Alison Macaulay, Keith A Wafford.
Abstract
Novel (E)-N(1)-(benzyl)cinnamamidines were prepared and evaluated as NR2B subtype NMDA receptor ligands. Excellent affinity was achieved by appropriate substitution of either phenyl ring. The 2-methoxybenzyl compound 1h had approximately 1,000-fold lower IC(50) in NR2B than NR2A-containing cells. Replacement of the styryl unit by 2-naphthyl was well tolerated.Entities:
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Year: 2003 PMID： 12639560 DOI： 10.1016/s0960-894x(02)01060-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823