| Literature DB >> 12638950 |
Ian Paterson1, Jose L Aceña, Jordi Bach, David Y K Chen, Mark J Coster.
Abstract
Simplified analogues of the potent antimitotic marine macrolide spongistatin 1/altohyrtin A were synthesised and evaluated as growth inhibitory agents against a range of human tumour cell lines, including Taxol-resistant strains, revealing that E-ring dehydration leads to enhanced cytotoxicity at the low picomolar level while truncation of the side-chain at C46 results in a drastic decrease in activity.Entities:
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Year: 2003 PMID： 12638950
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222