| Literature DB >> 12636402 |
Bao-Ning Su1, Eun Jung Park, Dejan Nikolic, Bernard D Santarsiero, Andrew D Mesecar, Jose Schunke Vigo, James G Graham, Fernando Cabieses, Richard B van Breemen, Harry H S Fong, Norman R Farnsworth, John M Pezzuto, A Douglas Kinghorn.
Abstract
Activity-monitored fractionation of a CHCl(3)-soluble extract of Deprea subtriflora using a quinone reductase induction assay led to the purification of subtrifloralactones A-J (1-10), 10 novel C-18 norwithanolides based on a new C(27) skeleton. These compounds were characterized by spectroscopic and chemical studies, and single-crystal X-ray diffraction analysis was used to confirm the structures of 1 and 4. Compounds 1-10 were evaluated for their cancer chemopreventive activity in terms of their ability to induce quinone reductase activity with cultured murine hepatoma cells, and compounds 1 and 6 were found to be highly effective.Entities:
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Year: 2003 PMID： 12636402 DOI： 10.1021/jo020542u
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354