Literature DB >> 12635664

Optic neuropathy in cancer patients. Report of a case possibly related to 5 fluorouracil toxicity and review of the literature.

L Delval1, J Klastersky.   

Abstract

We report the case of a 72-year-old woman suffering from bone metastatic breast cancer and treated with continuous intravenous 5 fluorouracil (5FU) chemotherapy, who presented with a bilateral asymmetric anterior optic neuropathy (ON). A deficiency of dihydropyrimidine dehydrogenase (DPD) was documented. Patients with DPD deficiency are at increased risk for developing unusual and/or severe toxicity to 5FU. We discuss the differential diagnosis of anterior ON and we suggest that 5FU can be responsible for optic nerve toxicity in patients with DPD deficiency.

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Year:  2002        PMID： 12635664     DOI： 10.1023/a:1020613600826

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  29 in total

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Journal:  J Neuroophthalmol       Date:  2001-09       Impact factor: 3.042

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  8 in total

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Authors:  Hao Jiang; Jing Lu; Jiang Ji
Journal:  Br J Pharmacol       Date:  2004-01-26       Impact factor: 8.739

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Authors:  Shinji Kobuchi; Yukako Ito; Kae Okada; Kazuki Imoto; Kanji Takada
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2012-11-30       Impact factor: 2.441

6.  Red American ginseng enhances the effect of fluorouracil on human colon cancer cells via both paraptosis and apoptosis pathways.

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7.  Bilateral optic disc oedema and associated optic neuropathy in the setting of FOLFOX chemotherapy.

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8.  Unilateral visual impairment in a patient undergoing chemotherapy: a case report and clinical findings.

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  8 in total

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