Literature DB >> 12635533

The beneficial effect of melatonin on chronic cyclosporin A nephrotoxicity in rats.

M Eşrefoğlu1, M Kuruş, E Sahna.   

Abstract

Cyclosporin A (CsA)-induced nephrotoxicity may be the consequence of oxidative stress. Anti-oxidant agents could be useful in reducing CsA toxicity. In this light microscopy study, tubular dilatation, atrophy, vacuolization and tubulointerstitial fibrosis were observed in rats given CsA, whereas in rats given CsA plus melatonin, no histological changes occurred. It is concluded that melatonin could be useful for reducing the nephrotoxic effects of CsA.

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Year:  2003        PMID： 12635533     DOI： 10.1177/147323000303100107

Source DB:  PubMed          Journal:  J Int Med Res        ISSN： 0300-0605            Impact factor:   1.671


  6 in total

1.  Provinol prevents CsA-induced nephrotoxicity by reducing reactive oxygen species, iNOS, and NF-kB expression.

Authors:  Barbara Buffoli; Olga Pechánová; Stanislava Kojsová; Ramaroson Andriantsitohaina; Lorena Giugno; Rossella Bianchi; Rita Rezzani
Journal:  J Histochem Cytochem       Date:  2005-06-13       Impact factor: 2.479

2.  Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: beneficial action of melatonin and N-acetylcysteine.

Authors:  A Kiersztan; K Winiarska; J Drozak; M Przedlacka; M Wegrzynowicz; T Fraczyk; J Bryla
Journal:  Mol Cell Biochem       Date:  2004-06       Impact factor: 3.396

3.  Effect of Isoproterenol on LDL Susceptibility to Oxidation and Serum Total Antioxidant Capacity in Cyclosporine-Treated Rats.

Authors:  H Foroughimoghaddam; A Ghorbanihaghjo; N Rashtchizadeh; H Argani
Journal:  Int J Organ Transplant Med       Date:  2010

4.  Effect of cyclosporine-a on paraoxonase activity in wistar rats.

Authors:  H Argani; A Ghorbanihaghjo; N Rashtchizadeh; S Seifirad; Y Rahbarfar
Journal:  Int J Organ Transplant Med       Date:  2011

5.  Melatonin Prevents Transforming Growth Factor-β1-Stimulated Transdifferentiation of Renal Interstitial Fibroblasts to Myofibroblasts by Suppressing Reactive Oxygen Species-Dependent Mechanisms.

Authors:  Jung-Yeon Kim; Jae-Hyung Park; Eon Ju Jeon; Jaechan Leem; Kwan-Kyu Park
Journal:  Antioxidants (Basel)       Date:  2020-01-01

6.  Protective Effects of Melatonin Against Aristolochic Acid-Induced Nephropathy in Mice.

Authors:  Jung-Yeon Kim; Jaechan Leem; Eon Ju Jeon
Journal:  Biomolecules       Date:  2019-12-19
  6 in total

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