| Literature DB >> 12635530 |
K Durak1, G Sonmez, B Sarisozen, S Ozkan, M Kaya, C Ozturk.
Abstract
To investigate the effect of alpha-tocopherol (vitamin E) on fracture healing in rabbits, two groups of 10 rabbits were either injected with alpha-tocopherol (treated) or untreated (controls). The right femurs of both groups were fractured, and the treated group were injected intramuscularly with 20 mg/kg alpha-tocopherol daily for 5 days starting on the day of fracture. After 21 days, histological sections of the fractured region were examined and scored. Fracture healing had progressed further in the alpha-tocopherol group than in the control group. A statistically significant difference between the histological grading of fracture healing in the two groups was found. This difference may result from an antioxidant (alpha-tocopherol) effect on free oxygen radicals in the fracture area. We conclude that alpha-tocopherol may affect fracture healing favourably and might be useful as a therapeutic agent in clinical fracture management.Entities:
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Year: 2003 PMID： 12635530 DOI： 10.1177/147323000303100104
Source DB: PubMed Journal: J Int Med Res ISSN： 0300-0605 Impact factor: 1.671