Literature DB >> 12635504

Role of endogenous retroviruses in autoimmune diseases.

Andras Perl1.   

Abstract

Endogenous retroviruses (ERVs) correspond to the integrated proviral form of infectious retroviruses that are trapped within the genome by mutations. Endogenous retroviruses represent a key molecular link between the host genome and infectious viral particles. Proteins encoded by ERVs are recognized by antiviral immune responses and become targets of autoreactivity. Activation of ERVs, such as human ERV-K or a human T-cell lymphotropic virus-related endogenous sequence, may also mediate pathogenicity of Epstein-Barr virus. Endogenous retrovirus peptides can directly regulate immune responses. Thus, molecular mimicry and immunomodulation by ERVs may account for self-reactivity and abnormal T- and B-cell functions in autoimmune disorders.

Entities:  

Mesh：

Year:  2003        PMID： 12635504     DOI： 10.1016/s0889-857x(02)00098-4

Source DB:  PubMed          Journal:  Rheum Dis Clin North Am        ISSN： 0889-857X            Impact factor:   2.670


  15 in total

1.  Infection in systemic lupus erythematosus: friend or foe?

Authors:  Lisa Francis; Andras Perl
Journal:  Int J Clin Rheumtol       Date:  2010-02-01

2.  Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray.

Authors:  Wolfgang Seifarth; Oliver Frank; Udo Zeilfelder; Birgit Spiess; Alex D Greenwood; Rüdiger Hehlmann; Christine Leib-Mösch
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

Review 3.  Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.

Authors:  Andras Perl
Journal:  Autoimmunity       Date:  2010-02       Impact factor: 2.815

4.  Pathogenic mechanisms in systemic lupus erythematosus.

Authors:  Andras Perl
Journal:  Autoimmunity       Date:  2010-02       Impact factor: 2.815

Review 5.  Retroelements and the human genome: new perspectives on an old relation.

Authors:  Norbert Bannert; Reinhard Kurth
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-13       Impact factor: 11.205

Review 6.  Human endogenous retroviruses: transposable elements with potential?

Authors:  P N Nelson; P Hooley; D Roden; H Davari Ejtehadi; P Rylance; P Warren; J Martin; P G Murray
Journal:  Clin Exp Immunol       Date:  2004-10       Impact factor: 4.330

Review 7.  Emerging new pathways of pathogenesis and targets for treatment in systemic lupus erythematosus and Sjogren's syndrome.

Authors:  Andras Perl
Journal:  Curr Opin Rheumatol       Date:  2009-09       Impact factor: 5.006

8.  Prevalence and risk factors for skin diseases among antiretroviral-naïve HIV-infected pregnant women in Dar es Salaam, Tanzania.

Authors:  Grace A Shayo; Candida Moshiro; Donna Spiegelman; Ferdinand M Mugusi; Guerino Chalamilla; Gernard Msamanga; Claudia Hawkins; Wafaie Fawzi
Journal:  Int J Dermatol       Date:  2014-07-29       Impact factor: 2.736

Review 9.  Endogenous retroviral pathogenesis in lupus.

Authors:  Andras Perl; David Fernandez; Tiffany Telarico; Paul E Phillips
Journal:  Curr Opin Rheumatol       Date:  2010-09       Impact factor: 5.006

Review 10.  Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE.

Authors:  Andras Perl; Gyorgy Nagy; Agnes Koncz; Peter Gergely; David Fernandez; Edward Doherty; Tiffany Telarico; Eduardo Bonilla; Paul E Phillips
Journal:  Autoimmunity       Date:  2008-05       Impact factor: 2.815
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