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Literature DB >> 12635262

Altered enzymes in ageing human fibroblasts.

Abstract

Diploid human fibroblasts accumulate heat labile enzymes during the final stages of their life-span in culture. The RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme. These observations support Orgel's "error catastrophe" theory of ageing.

Entities: Chemical Species

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Year: 1972 PMID： 12635262 DOI： 10.1038/238026a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

39 in total

1. Age-related changes associated with the induction of o-pyrocatechuic acid carboxylase in Aspergillus ornatus.

Authors: B M Spiegelman; B W Coursen
Journal: Arch Microbiol Date: 1975-06-20 Impact factor: 2.552

2. Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts.

Authors: S Linn; M Kairis; R Holliday
Journal: Proc Natl Acad Sci U S A Date: 1976-08 Impact factor: 11.205

3. Increased degradation rates of protein synthesized in hepatoma cells in the presence of amino acid analogues.

Authors: S E Knowles; J M Gunn; R W Hanson; F J Ballard
Journal: Biochem J Date: 1975-03 Impact factor: 3.857

4. Properties of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesized in hepatoma cells in the presence of amino acid analogues.

Authors: S E Knowles; J M Gunn; L Reshef; R W Hanson; F J Ballard
Journal: Biochem J Date: 1975-03 Impact factor: 3.857

Altered enzymes in ageing human fibroblasts.

1. Age-related changes associated with the induction of o-pyrocatechuic acid carboxylase in Aspergillus ornatus.

2. Decreased fidelity of DNA polymerase activity isolated from aging human fibroblasts.

3. Increased degradation rates of protein synthesized in hepatoma cells in the presence of amino acid analogues.

4. Properties of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesized in hepatoma cells in the presence of amino acid analogues.

5. Uracil-DNA glycosylase defective mutants of Ustilago maydis.

6. Mutator tRNAs are encoded by the Escherichia coli mutator genes mutA and mutC: a novel pathway for mutagenesis.

7. Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

Review 8. Microbiological effects of sublethal levels of antibiotics.

Review 9. Cellular aging--clonal senescence. A review (Part I).

10. Causes of aging are likely to be many: robin holliday and changing molecular approaches to cell aging, 1963-1988.