OBJECTIVE: The purpose of this study was to identify clinical signs and symptoms associated with detection of human papillomavirus (HPV) DNA in the female genital tract. STUDY DESIGN: A total of 516 university students (18 to 24 years old) enrolled in a cohort study that included the collection of genital specimens for HPV DNA testing every 4 months for up to 4 years. Reported symptoms and objective clinical findings of women with and without HPV DNA were compared by multivariate analysis. RESULTS: Acute and persisting HPV infections were not associated with discharge, itching, burning, soreness, or fissures. Clinical evidence of genital warts was statistically associated only with HPV types 6 and 11. Detection of any HPV DNA was associated with bacterial vaginosis (BV). Furthermore, a time lag analysis suggests that HPV infection usually precedes detection of BV. CONCLUSION: Most women who acquire genital HPV infection are asymptomatic; some, however, are at increased risk for BV.
OBJECTIVE: The purpose of this study was to identify clinical signs and symptoms associated with detection of human papillomavirus (HPV) DNA in the female genital tract. STUDY DESIGN: A total of 516 university students (18 to 24 years old) enrolled in a cohort study that included the collection of genital specimens for HPV DNA testing every 4 months for up to 4 years. Reported symptoms and objective clinical findings of women with and without HPV DNA were compared by multivariate analysis. RESULTS: Acute and persisting HPV infections were not associated with discharge, itching, burning, soreness, or fissures. Clinical evidence of genital warts was statistically associated only with HPV types 6 and 11. Detection of any HPV DNA was associated with bacterial vaginosis (BV). Furthermore, a time lag analysis suggests that HPV infection usually precedes detection of BV. CONCLUSION: Most women who acquire genital HPV infection are asymptomatic; some, however, are at increased risk for BV.
Authors: Kristine M Wylie; Todd N Wylie; Alison G Cahill; George A Macones; Methodius G Tuuli; Molly J Stout Journal: Am J Obstet Gynecol Date: 2018-05-05 Impact factor: 8.661
Authors: J C Borgogna; M D Shardell; E K Santori; T M Nelson; J M Rath; E D Glover; J Ravel; P E Gravitt; C J Yeoman; R M Brotman Journal: BJOG Date: 2019-11-20 Impact factor: 6.531
Authors: Su-Hsun Liu; Rebecca M Brotman; Jonathan M Zenilman; Patti E Gravitt; Derek A T Cummings Journal: J Infect Dis Date: 2013-07-24 Impact factor: 5.226
Authors: Rachel L Winer; Tiffany G Harris; Long Fu Xi; Kathrin U Jansen; James P Hughes; Qinghua Feng; Carolee Welebob; Jesse Ho; Shu-Kuang Lee; Joseph J Carter; Denise A Galloway; Nancy B Kiviat; Laura A Koutsky Journal: J Med Virol Date: 2009-04 Impact factor: 2.327
Authors: S A Lippman; M C A Sucupira; H E Jones; C G Luppi; J Palefsky; J H H M van de Wijgert; R L S Oliveira; R S Diaz Journal: Int J STD AIDS Date: 2010-02 Impact factor: 1.359