Literature DB >> 12634401

Treatment of human immunodeficiency virus type 1 virions depleted of cyclophilin A by natural endogenous reverse transcription restores infectivity.

Mahfuz Khan1, Minerva Garcia-Barrio, Michael D Powell.   

Abstract

We have previously shown that virions with nef deleted can be restored to wild-type infectivity by treatment to induce natural endogenous reverse transcription (NERT). Since Nef and cyclophilin A (CyPA) appear to act in similar ways on postentry events, we determined whether NERT treatment would restore infectivity to virions depleted of CyPA. Our results show that the infectivity of virions depleted of CyPA by treatment with cyclosporine A could be restored by NERT treatment, while mutants in the CyPA binding loop of capsid could only be partially restored. These results suggest that CyPA is involved in some aspect of the uncoating process.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12634401      PMCID： PMC150660          DOI： 10.1128/jvi.77.7.4431-4434.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  29 in total

1.  CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A.

Authors:  T Pushkarsky; G Zybarth; L Dubrovsky; V Yurchenko; H Tang; H Guo; B Toole; B Sherry; M Bukrinsky
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

2.  A mutation in the human immunodeficiency virus type 1 transmembrane glycoprotein gp41 dominantly interferes with fusion and infectivity.

Authors:  E O Freed; E L Delwart; G L Buchschacher; A T Panganiban
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

3.  Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.

Authors:  M Khan; M Garcia-Barrio; M D Powell
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

4.  Functional association of cyclophilin A with HIV-1 virions.

Authors:  M Thali; A Bukovsky; E Kondo; B Rosenwirth; C T Walsh; J Sodroski; H G Göttlinger
Journal:  Nature       Date:  1994-11-24       Impact factor: 49.962

5.  Morphologic changes in human immunodeficiency virus type 1 virions secondary to intravirion reverse transcription: evidence indicating that reverse transcription may not take place within the intact viral core.

Authors:  H Zhang; G Dornadula; J Orenstein; R J Pomerantz
Journal:  J Hum Virol       Date:  2000 May-Jun

6.  Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A.

Authors:  Daryl A Bosco; Elan Z Eisenmesser; Susan Pochapsky; Wesley I Sundquist; Dorothee Kern
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-02       Impact factor: 11.205

7.  Cyclophilin a plays distinct roles in human immunodeficiency virus type 1 entry and postentry events, as revealed by spinoculation.

Authors:  Andrew C S Saphire; Michael D Bobardt; Philippe A Gallay
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

8.  Cyclophilin A-independent replication of a human immunodeficiency virus type 1 isolate carrying a small portion of the simian immunodeficiency virus SIV(MAC) gag capsid region.

Authors:  M Fujita; A Yoshida; M Miyaura; A Sakurai; H Akari; A H Koyama; A Adachi
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

9.  trans-Complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity.

Authors:  Andrew C S Saphire; Michael D Bobardt; Philippe A Gallay
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

10.  Cyclophilin: a specific cytosolic binding protein for cyclosporin A.

Authors:  R E Handschumacher; M W Harding; J Rice; R J Drugge; D W Speicher
Journal:  Science       Date:  1984-11-02       Impact factor: 47.728
View more
  7 in total

1.  Characterization of Nef-CXCR4 interactions important for apoptosis induction.

Authors:  Ming-Bo Huang; Ling Ling Jin; Cleve O James; Mahfuz Khan; Michael D Powell; Vincent C Bond
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

2.  Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.

Authors:  Theodora Hatziioannou; David Perez-Caballero; Simone Cowan; Paul D Bieniasz
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

3.  Reverse transcription complex: the key player of the early phase of HIV replication.

Authors:  Sergey Iordanskiy; Michael Bukrinsky
Journal:  Future Virol       Date:  2007-01-01       Impact factor: 1.831

4.  The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability.

Authors:  Jiyang Jiang; Sherimay D Ablan; Suchitra Derebail; Kamil Hercík; Ferri Soheilian; James A Thomas; Shixing Tang; Indira Hewlett; Kunio Nagashima; Robert J Gorelick; Eric O Freed; Judith G Levin
Journal:  Virology       Date:  2011-10-26       Impact factor: 3.616

5.  Chimeric human immunodeficiency virus type 1 virions that contain the simian immunodeficiency virus nef gene are cyclosporin A resistant.

Authors:  Mahfuz Khan; Lingling Jin; Lesa Miles; Vincent C Bond; Michael D Powell
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

6.  Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment.

Authors:  Mahfuz Khan; Lingling Jin; Ming Bo Huang; Lesa Miles; Vincent C Bond; Michael D Powell
Journal:  J Virol       Date:  2004-02       Impact factor: 5.103

7.  Human immunodeficiency virus type 1 N-terminal capsid mutants containing cores with abnormally high levels of capsid protein and virtually no reverse transcriptase.

Authors:  Shixing Tang; Tsutomu Murakami; Naiqian Cheng; Alasdair C Steven; Eric O Freed; Judith G Levin
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.