| Literature DB >> 12634396 |
Sallie R Permar1, Sherry A Klumpp, Keith G Mansfield, Woong-Ki Kim, Darci A Gorgone, Michelle A Lifton, Kenneth C Williams, Jörn E Schmitz, Keith A Reimann, Michael K Axthelm, Fernando P Polack, Diane E Griffin, Norman L Letvin.
Abstract
The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.Entities:
Mesh：
Substances：
Year: 2003 PMID： 12634396 PMCID： PMC150640 DOI： 10.1128/jvi.77.7.4396-4400.2003
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103