AIMS: to investigate a possible association of cortisol stress response during early abstention with relapse. METHODS: Thirty-six alcohol-dependent males, half of them with a comorbid anxiety disorder, and 15 healthy controls were exposed to a standardized psychosocial stress test. Thirty-one of the patients were assessed for relapse 6 weeks after discharge. RESULTS: The relapsers showed almost no cortisol responses in the stress test. Comorbid anxiety disorder influenced neither stress response nor relapse. CONCLUSIONS: During early abstention from alcohol, reduced stress-responsivity of the hypothalamo-pituitary-adrenocortical axis seems to be connected to early relapse.
AIMS: to investigate a possible association of cortisol stress response during early abstention with relapse. METHODS: Thirty-six alcohol-dependent males, half of them with a comorbid anxiety disorder, and 15 healthy controls were exposed to a standardized psychosocial stress test. Thirty-one of the patients were assessed for relapse 6 weeks after discharge. RESULTS: The relapsers showed almost no cortisol responses in the stress test. Comorbid anxiety disorder influenced neither stress response nor relapse. CONCLUSIONS: During early abstention from alcohol, reduced stress-responsivity of the hypothalamo-pituitary-adrenocortical axis seems to be connected to early relapse.
Authors: Amanda K Gilmore; Constance Guille; Nathaniel L Baker; Kathleen T Brady; Christine K Hahn; Callah M Davis; Jenna L McCauley; Sudie E Back Journal: Addict Behav Date: 2019-01-05 Impact factor: 3.913
Authors: Rajita Sinha; Helen C Fox; Kwangik A Hong; Keri Bergquist; Zubin Bhagwagar; Kristen M Siedlarz Journal: Neuropsychopharmacology Date: 2008-06-18 Impact factor: 7.853