BACKGROUND: To examine associations of weight loss and changes in fat distribution with changes in blood pressure and the remission of hypertension in a community-based sample. METHODS: Participants were 3245 white and African-American men and women, 45-64 years of age, who participated in the Atherosclerosis Risk in Communities Study over an average of 9 years. Mixed models analyses were used to examine the associations of weight loss and changes in fat distribution with changes in blood pressure. Proportional hazard models with time-dependent covariates were used to examine the associations of weight loss and changes in fat distribution with the remission of hypertension. RESULTS: Weight loss was associated with a decrease in systolic blood pressure and diastolic blood pressure and with an increased rate of remission of hypertension. Hazard ratios of the remission of hypertension associated with 1-kg increment in annual weight loss were 2.04 (95% confidence interval [CI]: 1.62-2.59), 1.38 (95% CI: 1.14-1.67), 1.84 (95% CI: 1.47-2.29), and 1.53 (95% CI: 1.14-2.05) for white women, African-American women, white men, and African-American men, respectively. Changes in fat distribution were associated with the remission of hypertension in younger (45-54 years) participants. CONCLUSIONS: Weight loss was associated with a decrease in blood pressure and with remission of hypertension in white and African-American men and women.
BACKGROUND: To examine associations of weight loss and changes in fat distribution with changes in blood pressure and the remission of hypertension in a community-based sample. METHODS:Participants were 3245 white and African-American men and women, 45-64 years of age, who participated in the Atherosclerosis Risk in Communities Study over an average of 9 years. Mixed models analyses were used to examine the associations of weight loss and changes in fat distribution with changes in blood pressure. Proportional hazard models with time-dependent covariates were used to examine the associations of weight loss and changes in fat distribution with the remission of hypertension. RESULTS:Weight loss was associated with a decrease in systolic blood pressure and diastolic blood pressure and with an increased rate of remission of hypertension. Hazard ratios of the remission of hypertension associated with 1-kg increment in annual weight loss were 2.04 (95% confidence interval [CI]: 1.62-2.59), 1.38 (95% CI: 1.14-1.67), 1.84 (95% CI: 1.47-2.29), and 1.53 (95% CI: 1.14-2.05) for white women, African-American women, white men, and African-American men, respectively. Changes in fat distribution were associated with the remission of hypertension in younger (45-54 years) participants. CONCLUSIONS:Weight loss was associated with a decrease in blood pressure and with remission of hypertension in white and African-American men and women.
Authors: Lisa de las Fuentes; Giovanni de Simone; Donna K Arnett; Víctor G Dávila-Román Journal: Endocr Metab Immune Disord Drug Targets Date: 2010-06 Impact factor: 2.895
Authors: Christianne L Roumie; Xulei Liu; Neesha N Choma; Robert A Greevy; Adriana M Hung; Carlos G Grijalva; Marie R Griffin Journal: Pharmacoepidemiol Drug Saf Date: 2012-03-19 Impact factor: 2.890
Authors: Joanna M N Guimarães; Rosane H Griep; Maria J M Fonseca; Bruce B Duncan; Maria I Schmidt; José G Mill; Paulo A Lotufo; Isabela J Bensenor; Sandhi M Barreto; Luana Giatti; Sheila M A Matos; Maria delC B Molina; Antonio G Pacheco; Dora Chor Journal: J Hum Hypertens Date: 2019-11-18 Impact factor: 3.012
Authors: Katie A Rickel; Vanessa A Milsom; Kathryn M Ross; Valerie J Hoover; Ninoska D Peterson; Michael G Perri Journal: Ethn Dis Date: 2011 Impact factor: 1.847
Authors: Amalia Karahalios; Laura Baglietto; John B Carlin; Dallas R English; Julie A Simpson Journal: BMC Med Res Methodol Date: 2012-07-11 Impact factor: 4.615
Authors: Abhijit V Kshirsagar; Ya-Lin Chiu; Andrew S Bomback; Phyllis A August; Anthony J Viera; Romulo E Colindres; Heejung Bang Journal: J Clin Hypertens (Greenwich) Date: 2010-10 Impact factor: 3.738
Authors: Monica C Klempel; Cynthia M Kroeger; Surabhi Bhutani; John F Trepanowski; Krista A Varady Journal: Nutr J Date: 2012-11-21 Impact factor: 3.271