| Literature DB >> 12633875 |
Luigi Barbieri1, Maurizio Brigotti, Paolo Perocco, Domenica Carnicelli, Marialibera Ciani, Laura Mercatali, Fiorenzo Stirpe.
Abstract
It has been known that ribosome-inactivating proteins (RIPs) from plants damage ribosomes by removing adenine from a precise position of rRNA. Subsequently it was observed that all tested RIPs depurinate DNA, and some of them also non-ribosomal RNAs and poly(A), hence the denomination of adenine polynucleotide glycosylases was proposed. We report now that ricin, saporin-L2, saporin-S6, gelonin and momordin depurinate also poly(ADP-ribosyl)ated poly(ADP-ribose) polymerase (auto modified enzyme), an enzyme involved in DNA repair. We observed also that all RIPs but gelonin induce transformation of fibroblasts, possibly as a consequence of damage to DNA and of the altered DNA repair system.Entities:
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Year: 2003 PMID： 12633875 DOI： 10.1016/s0014-5793(03)00176-5
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124