Literature DB >> 12633670

Regulation of thymocyte development: only the meek survive.

Paul E Love1, Andrew C Chan.   

Abstract

T cell antigen receptor-induced signals are required for normal T cell development and function. Recent studies have investigated the mechanism(s) by which signals of different strengths are converted into distinct cellular fates during thymocyte development. These studies indicate the importance of the strength and duration of signals activated through PLC and PKC pathways in shaping the mature TCR repertoire.

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Year:  2003        PMID： 12633670     DOI： 10.1016/s0952-7915(03)00002-5

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  6 in total

1.  Ikaros is required to survive positive selection and to maintain clonal diversity during T-cell development in the thymus.

Authors:  Kevin W Tinsley; Changwan Hong; Megan A Luckey; Joo-Young Park; Grace Y Kim; Hee-Won Yoon; Hilary R Keller; Andrew J Sacks; Lionel Feigenbaum; Jung-Hyun Park
Journal:  Blood       Date:  2013-08-01       Impact factor: 22.113

2.  Expression and activity of multidrug resistance protein 1 in a murine thymoma cell line.

Authors:  Juliana Echevarria-Lima; Fernanda Kyle-Cezar; Daniela F P Leite; Luiz Capella; Márcia A M Capella; Vivian M Rumjanek
Journal:  Immunology       Date:  2005-04       Impact factor: 7.397

3.  Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.

Authors:  Meghan L Rudd; Alymarie Tua-Smith; David B Straus
Journal:  Mol Cell Biol       Date:  2006-08-21       Impact factor: 4.272

Review 4.  IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis?

Authors:  Partha S Biswas; Govind Bhagat; Alessandra B Pernis
Journal:  Immunol Rev       Date:  2010-01       Impact factor: 12.988

5.  Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.

Authors:  Margaret D Myers; Leonard L Dragone; Arthur Weiss
Journal:  J Cell Biol       Date:  2005-07-18       Impact factor: 10.539

6.  TM1 and TM2: two mutant alleles that constitute a genetic trait controlling thymocyte development.

Authors:  Fang Huang; Mayumi Naramura; Virginia E Papaioannou; Hua Gu
Journal:  Immunogenetics       Date:  2007-04-04       Impact factor: 3.330
  6 in total

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