Literature DB >> 12633079

P[N(i-Bu)CH2CH2]3N: a versatile ligand for the Pd-catalyzed amination of aryl chlorides.

Sameer Urgaonkar1, M Nagarajan, John G Verkade.   

Abstract

[reaction: see text] Palladium-catalyzed amination reactions of aryl chlorides with amines proceeded in the presence of the bicyclic triaminophosphine P[N(i-Bu)CH(2)CH(2)](3)N to afford the corresponding arylamines in good to excellent yields. Electron-poor, electron-neutral, and electron-rich aryl chlorides all participated with equal ease.

Entities:  

Year:  2003        PMID： 12633079     DOI： 10.1021/ol027450b

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Studies on high-temperature amination reactions of aromatic chlorides using discrete palladium-N-heterocyclic carbene (NHC) complexes and in situ palladium/imidazolium salt protocols.

Authors:  Andrew J McCarroll; David A Sandham; Lisa R Titcomb; Alexandra K de K Lewis; F Geoffrey N Cloke; Brian P Davies; Alejandro Perez de Santana; Wolfgang Hiller; Stephen Caddick
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

2.  Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase.

Authors:  Alka Marwaha; John White; Farah El Mazouni; Sharon A Creason; Sreekanth Kokkonda; Frederick S Buckner; Susan A Charman; Margaret A Phillips; Pradipsinh K Rathod
Journal:  J Med Chem       Date:  2012-08-21       Impact factor: 7.446
  2 in total

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