| Literature DB >> 1263279 |
L J Fischer, J L Weissinger, D E Rickert, K L Hintze.
Abstract
Studies were conducted to elucidate the processes involved in the biological disposition of diethylstilbestrol (DES). The apparent biological half-life of [14C] DES decreased with increasing age in immature rats. The half-life of DES in adult rats (14 min) was reached between the 15th and 25th day after birth. Comparison of the intestinal absorption of [14C] DES and [14C]DES monoglucuronide showed the unconjugated drug to be absorbed much more rapidly. Hydrolysis of the conjugate took place in the lower intestine, and this permitted the drug to undergo enterohepatic cycling.Entities:
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Year: 1976 PMID： 1263279 DOI： 10.1080/15287397609529360
Source DB: PubMed Journal: J Toxicol Environ Health ISSN： 0098-4108