AIM: To further characterize the possible relationship between the molecular changes and prognosis of ESC and to elucidate the possible mechanisms involved. METHODS: 114 specimens of ESC were collected from Linzhou city, and all patients were followed up for more than 5 years after resection. Histopathological analysis and immunohistochemical staining (ABC) were employed to detect the alteration of MUC1. RESULTS: The positive immunostaining rate for MUC1 was 79 % (90/114), and the high-expression rate was 63 % (72/114). The mean survival periods (months) of those with high- and low-expression rates of MUC1 were 41 (95 % CI: 35, 47) and 52 (95 % CI: 45, 59), respectively. Patients in the low-expression group obviously survived longer than those in high-expression group, and the difference was significant (P<0.05). The expression of MUC1 protein in the esophageal carcinoma specimens with metastasis was stronger than those without metastasis, the difference was also significant (P<0.05). The stepwise multivariate analysis showed that "differentiation", "expression of MUC1" and "TNM staging" were the most important factors affecting the prognosis of esophageal carcinoma patients (P<0.05). CONCLUSION: A good correlation between the alteration of MUC1 and the regional lymph node metastasis was observed. Furthermore, high-expression of MUC1 was associated with poor prognosis for esophageal cancer patients. These results indicated that MUC1 is a promising biomarker for predicting lymph node metastasis and prognosis in esophageal cancer.
AIM: To further characterize the possible relationship between the molecular changes and prognosis of ESC and to elucidate the possible mechanisms involved. METHODS: 114 specimens of ESC were collected from Linzhou city, and all patients were followed up for more than 5 years after resection. Histopathological analysis and immunohistochemical staining (ABC) were employed to detect the alteration of MUC1. RESULTS: The positive immunostaining rate for MUC1 was 79 % (90/114), and the high-expression rate was 63 % (72/114). The mean survival periods (months) of those with high- and low-expression rates of MUC1 were 41 (95 % CI: 35, 47) and 52 (95 % CI: 45, 59), respectively. Patients in the low-expression group obviously survived longer than those in high-expression group, and the difference was significant (P<0.05). The expression of MUC1 protein in the esophageal carcinoma specimens with metastasis was stronger than those without metastasis, the difference was also significant (P<0.05). The stepwise multivariate analysis showed that "differentiation", "expression of MUC1" and "TNM staging" were the most important factors affecting the prognosis of esophageal carcinomapatients (P<0.05). CONCLUSION: A good correlation between the alteration of MUC1 and the regional lymph node metastasis was observed. Furthermore, high-expression of MUC1 was associated with poor prognosis for esophageal cancerpatients. These results indicated that MUC1 is a promising biomarker for predicting lymph node metastasis and prognosis in esophageal cancer.
Authors: P Guillem; V Billeret; M P Buisine; J F Flejou; M Lecomte-Houcke; P Degand; J P Aubert; J P Triboulet; N Porchet Journal: Int J Cancer Date: 2000-12-15 Impact factor: 7.396
Authors: Sigurd Kraus; Paul D Abel; Christian Nachtmann; Hans-Jörg Linsenmann; Wolfgang Weidner; Gordon W H Stamp; Khurram S Chaudhary; Stephen E Mitchell; Folker E Franke; El-Nasir Lalani Journal: Hum Pathol Date: 2002-01 Impact factor: 3.466
Authors: H Kijima; O Chino; G Oshiba; H Tanaka; T Kenmochi; Y Kise; H Shimada; Y Abe; T Tokunaga; H Yamazaki; M Nakamura; M Tanaka; H Makuuchi; Y Ueyama Journal: Anticancer Res Date: 2001 Mar-Apr Impact factor: 2.480
Authors: S E Baldus; T K Zirbes; J Glossmann; S Fromm; F G Hanisch; S P Mönig; W Schröder; P M Schneider; U Flucke; U Karsten; J Thiele; A H Hölscher; H P Dienes Journal: Oncology Date: 2001 Impact factor: 2.935
Authors: M Sagara; S Yonezawa; K Nagata; Y Tezuka; S Natsugoe; P X Xing; I F McKenzie; T Aikou; E Sato Journal: Int J Cancer Date: 1999-06-21 Impact factor: 7.396