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Literature DB >> 1263097

Fluorometric assay of verapamil in biological fluids and tissues.

Abstract

Verapamil concentrations in blood, urinee, or tissue homogenates may be measured fluorometrically in the 0.1-10-mug/ml range after extraction into heptane and back-extraction into acid; recovery rates are above 87%. The drug apparently is eliminated rapidly in guinea pigs, with a plasma half-life of 45 min.

Entities: Chemical Species

Mesh：

Substances：
Verapamil

Year: 1976 PMID： 1263097 DOI： 10.1002/jps.2600650330

Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534

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Cited

11 in total

1. Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L-verapamil using stable isotope-labelled verapamil.

Authors: M Eichelbaum; A Somogyi; G E von Unruh; H J Dengler
Journal: Eur J Clin Pharmacol Date: 1981-01 Impact factor: 2.953

2. Effects of verapamil on ventricular tachycardias possibly caused by reentry, automaticity, and triggered activity.

Authors: R J Sung; W A Shapiro; E N Shen; F Morady; J Davis
Journal: J Clin Invest Date: 1983-07 Impact factor: 14.808

Review 3. Verapamil: a review of its pharmacological properties and therapeutic use.

Authors: B N Singh; G Ellrodt; C T Peter
Journal: Drugs Date: 1978-03 Impact factor: 9.546

4. Antiarrhythmic actions of verapamil against ischaemic arrhythmias in the rat.

Authors: M J Curtis; B A MacLeod; M J Walker
Journal: Br J Pharmacol Date: 1984-10 Impact factor: 8.739

Review 5. Clinical pharmacokinetics of verapamil.

Authors: S R Hamann; R A Blouin; R G McAllister
Journal: Clin Pharmacokinet Date: 1984 Jan-Feb Impact factor: 6.447

6. Effect of verapamil on blood pressure and lesions in heart and kidney of rats made hypertensive by deoxycorticosterone (DOC).

Authors: A P Aguas; P A Nickerson
Journal: Am J Pathol Date: 1983-01 Impact factor: 4.307

Fluorometric assay of verapamil in biological fluids and tissues.

1. Simultaneous determination of the intravenous and oral pharmacokinetic parameters of D,L-verapamil using stable isotope-labelled verapamil.

2. Effects of verapamil on ventricular tachycardias possibly caused by reentry, automaticity, and triggered activity.

Review 3. Verapamil: a review of its pharmacological properties and therapeutic use.

4. Antiarrhythmic actions of verapamil against ischaemic arrhythmias in the rat.

Review 5. Clinical pharmacokinetics of verapamil.

6. Effect of verapamil on blood pressure and lesions in heart and kidney of rats made hypertensive by deoxycorticosterone (DOC).

7. The effects on left ventricular performance of nifedipine and verapamil in exercise-induced angina pectoris.

Review 8. Calcium antagonists. Pharmacokinetic properties.

Review 9. Calcium antagonists. Clinical use in the treatment of arrhythmias.

10. Clinical pharmacokinetics of verapamil in patients with atrial fibrillation.