| Literature DB >> 12630739 |
Yu Chen1, Dharmesh R Tailor, Xavier Intes, Britton Chance.
Abstract
We measure the tissue oxygen and haemoglobin concentrations in the rat brain during modulation of inhaled oxygen concentration (FiO2), using non-invasive frequency domain near-infrared oximetry. The rise in oxygenated haemoglobin concentration and the decline in deoxygenated haemoglobin concentration are demonstrated in correspondence with the modulation of FiO2, which is changed from 20% to 100% in increments of 20%. Furthermore, the tissue oxygenation saturation also shows the corresponding trend and changes ranging from approximately 70% to 90%. The relative changes in deoxygenated haemoglobin concentration are compared to the blood-oxygenation-level-dependent (BOLD) MRI signal recorded during a similar FiO2 protocol. A linear relationship with high correlation coefficient between the relative changes in the BOLD MRI signal and the NIRS signal is observed.Entities:
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Year: 2003 PMID: 12630739 DOI: 10.1088/0031-9155/48/4/301
Source DB: PubMed Journal: Phys Med Biol ISSN: 0031-9155 Impact factor: 3.609