| Literature DB >> 12628678 |
Anastasia Nikolakakis1, Khadidja Haidara, Françoise Sauriol, Orval Mamer, Lolita O Zamir.
Abstract
A 7beta-O-glycosylated docetaxel analogue was semi-synthesized from 9-dihydro-13-acetylbaccatin III, the most abundant taxane isolated from the needles of Taxus canadensis. It was shown to be more bioactive than paclitaxel according to the tubulin assay. It had a reduced potency in the MCF7 cell line cytotoxicity assay compared to paclitaxel, but it demonstrated better activity against the drug resistant cell line MCF7-ADR. In addition, the presence of one sugar moiety on C-7 doubled the water solubility versus that of paclitaxel.Entities:
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Year: 2003 PMID： 12628678 DOI： 10.1016/s0968-0896(02)00607-7
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641