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Literature DB >> 1262866

The isolated perfused chicken heart as a tool for studying acetylcholine output in the absence of cholinesterase inhibition.

Abstract

In chicken hearts, the acetylcholine (ACh) output in response to vagal stimulation was easily detectable by gas chromatography even in the absence of cholinesterase inhibition. Eserine 10(-6) M markedly increased the ACh output. In contrast, the ACh output from the perfused rabbit heart was not measurable in the absence of cholinesterase inhibition. Both ACh concentration and cholinesterase activity were higher in the chicken heart than in the rabbit heart. In conclusion, the isolated perfused chicken heart is at present a unique tool for studying the output of the parasympathetic transmitter in the absence of cholinesterase inhibition.

Entities: Chemical Gene Species

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Year: 1976 PMID： 1262866 DOI： 10.1007/BF01254136

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

13 in total

1. Proceedings: Modulation by oxotremorine and atropine of acetylcholine release evoked by electrical stimulation of guinea-pig ileum longitudinal muscle strips.

Authors: H Kilbinger
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

2. A new and rapid colorimetric determination of acetylcholinesterase activity.

Authors: G L ELLMAN; K D COURTNEY; V ANDRES; R M FEATHER-STONE
Journal: Biochem Pharmacol Date: 1961-07 Impact factor: 5.858

3. Intramural nerves in the ventricular myocardium of the domestic fowl and other animals.

Authors: T B Bolton
Journal: Br J Pharmacol Chemother Date: 1967-10

4. [Negative inotropic effects of endogenous acetylcholine on ventricular myocardium of cat and chicken].

Authors: G Kissling; K Reutter; G Sieber; H Nguyen-Duong; R Jacob
Journal: Pflugers Arch Date: 1972 Impact factor: 3.657

5. Atropine-like properties of hemicholinium-3.

Authors: A Bertolini; A Greggia; W Ferrari
Journal: Life Sci Date: 1967-03-01 Impact factor: 5.037

6. [On an acute anti-acetylcholine effect of hemicholinium no. 3 on the guinea pig atrium].

Authors: D Bieger; H Lüllmann; O Wassermann
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1968

7. Neuronal and extraneuronal uptake and efflux of catecholamines in the isolated rabbit heart.

Authors: R Lindmar; K Löffelholz
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1974 Impact factor: 3.000

8. Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorine.

Authors: J C Szerb; G T Somogyi
Journal: Nat New Biol Date: 1973-01-24

9. Demonstration of acetylcholine release by measuring efflux of labelled choline from cerebral cortical slices.

Authors: G T Somogyi; J C Szerb
Journal: J Neurochem Date: 1972-11 Impact factor: 5.372

10. The binding of acetylcholine to receptors and its removal from the synaptic cleft.

Authors: B Katz; R Miledi
Journal: J Physiol Date: 1973-06 Impact factor: 5.182

8 in total

1. Acetylcholine overflow during infusion of a high potassium-low sodium solution into the perfused chicken heart in the absence and presence of physostigmine.

Authors: R Lindmar; K Löffelholz; H Pompetzki
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-08 Impact factor: 3.000

The isolated perfused chicken heart as a tool for studying acetylcholine output in the absence of cholinesterase inhibition.

1. Proceedings: Modulation by oxotremorine and atropine of acetylcholine release evoked by electrical stimulation of guinea-pig ileum longitudinal muscle strips.

2. A new and rapid colorimetric determination of acetylcholinesterase activity.

3. Intramural nerves in the ventricular myocardium of the domestic fowl and other animals.

4. [Negative inotropic effects of endogenous acetylcholine on ventricular myocardium of cat and chicken].

5. Atropine-like properties of hemicholinium-3.

6. [On an acute anti-acetylcholine effect of hemicholinium no. 3 on the guinea pig atrium].

7. Neuronal and extraneuronal uptake and efflux of catecholamines in the isolated rabbit heart.

8. Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorine.

9. Demonstration of acetylcholine release by measuring efflux of labelled choline from cerebral cortical slices.

10. The binding of acetylcholine to receptors and its removal from the synaptic cleft.

1. Acetylcholine overflow during infusion of a high potassium-low sodium solution into the perfused chicken heart in the absence and presence of physostigmine.

2. Modification of vagal action on the toad heart by changes in flow.

3. Effect of coronary perfusion rate on the hydrolysis of exogenous and endogenous acetylcholine in the isolated heart.

4. Acetylcholine overflow from isolated perfused hearts of various species in the absence of cholinesterase inhibition.

5. The role of choline in the release of acetylcholine in isolated hearts.

6. Evidence for bilateral vagal innervation of postganglionic parasympathetic neurons in chicken heart.

7. The fade of the response to acetylcholine at the rabbit isolated sino-atrial node.

8. Interstitial washout and hydrolysis of acetylcholine in the perfused heart.