Literature DB >> 12628351

GIP or not GIP? That is the question.

Timothy J Kieffer1.   

Abstract

Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is released during a meal and facilitates the disposal of both glucose and fat. Because of the insulinotropic action of GIP, this hormone has been considered as a potential therapy of type 2 diabetes, where insulin secretion is inadequate. However, a recent study using GIP receptor knockout mice suggests that inhibition of GIP signalling might be a new target for anti-obesity drugs.

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Year:  2003        PMID： 12628351     DOI： 10.1016/S0165-6147(03)00031-2

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  11 in total

Review 1.  Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa.

Authors:  A Torsello; F Brambilla; L Tamiazzo; I Bulgarelli; D Rapetti; E Bresciani; V Locatelli
Journal:  J Endocrinol Invest       Date:  2007-12       Impact factor: 4.256

2.  Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents.

Authors:  C E Moss; W J Marsh; H E Parker; E Ogunnowo-Bada; C H Riches; A M Habib; M L Evans; F M Gribble; F Reimann
Journal:  Diabetologia       Date:  2012-08-08       Impact factor: 10.122

Review 3.  Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology.

Authors:  Dominique Bataille
Journal:  J Mol Med (Berl)       Date:  2007-03-14       Impact factor: 4.599

4.  Adipocyte expression of the glucose-dependent insulinotropic polypeptide receptor involves gene regulation by PPARγ and histone acetylation.

Authors:  Su-Jin Kim; Cuilan Nian; Christopher H S McIntosh
Journal:  J Lipid Res       Date:  2011-01-18       Impact factor: 5.922

5.  Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells.

Authors:  H E Parker; A M Habib; G J Rogers; F M Gribble; F Reimann
Journal:  Diabetologia       Date:  2008-12-11       Impact factor: 10.122

6.  Characterization of a Novel Intestinal Glycerol-3-phosphate Acyltransferase Pathway and Its Role in Lipid Homeostasis.

Authors:  Irani Khatun; Ronald W Clark; Nicholas B Vera; Kou Kou; Derek M Erion; Timothy Coskran; Walter F Bobrowski; Carlin Okerberg; Bryan Goodwin
Journal:  J Biol Chem       Date:  2015-12-07       Impact factor: 5.157

7.  Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.

Authors:  V A Gault; P L McClean; R S Cassidy; N Irwin; P R Flatt
Journal:  Diabetologia       Date:  2007-06-09       Impact factor: 10.122

8.  Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice.

Authors:  Satoko Shimazu-Kuwahara; Norio Harada; Shunsuke Yamane; Erina Joo; Akiko Sankoda; Timothy J Kieffer; Nobuya Inagaki
Journal:  Mol Metab       Date:  2017-01-19       Impact factor: 7.422

9.  Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development.

Authors:  David A Cameron; Frank A Middleton; Anjen Chenn; Eric C Olson
Journal:  BMC Neurosci       Date:  2012-08-01       Impact factor: 3.288

10.  Vaccination against GIP for the treatment of obesity.

Authors:  Alma Fulurija; Thomas A Lutz; Katja Sladko; Melania Osto; Peter Y Wielinga; Martin F Bachmann; Philippe Saudan
Journal:  PLoS One       Date:  2008-09-09       Impact factor: 3.240
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