OBJECTIVES: Subcortical vascular dementia (SVD) is associated with white matter lesions and demyelination. The aim of the present study was to examine the cerebrospinal fluid (CSF) levels of TNF-alpha, a proinflammatory cytokine mediating myelin damage, in SVD patients. The intrathecal TNF-alpha levels were related to the clinical symptoms of dementia, as well as to intrathecal levels of sulfatide, a marker of white matter degradation, and of neurofilament, a marker of neuronal degeneration. METHODS: CSF levels of TNF-a, sulfatide and neurofilament were all analyzed by immunoenzymatic procedures in 17 patients with SVD and in 26 healthy controls. RESULTS: The intrathecal concentration of TNF-alpha was significantly increased in SVD patients compared to healthy controls (p = 0.0001). The intrathecal levels of TNF-alpha were significantly correlated (r = 0.6, p = 0.02) to the levels of sulfatide, but not to the levels of neurofilament, (r = 0.08, NS). CONCLUSIONS: We have demonstrated intrathecal production of TNF-alpha in SVD patients. The correlation between TNF-a and sulfatide levels in the CSF suggests that this apoptosis-inducing cytokine leads to the death of oligodendrocytes, thereby contributing to white matter degeneration, a hallmark of SVD. Copyright 2003 S. Karger AG, Basel
OBJECTIVES:Subcortical vascular dementia (SVD) is associated with white matter lesions and demyelination. The aim of the present study was to examine the cerebrospinal fluid (CSF) levels of TNF-alpha, a proinflammatory cytokine mediating myelin damage, in SVDpatients. The intrathecal TNF-alpha levels were related to the clinical symptoms of dementia, as well as to intrathecal levels of sulfatide, a marker of white matter degradation, and of neurofilament, a marker of neuronal degeneration. METHODS: CSF levels of TNF-a, sulfatide and neurofilament were all analyzed by immunoenzymatic procedures in 17 patients with SVD and in 26 healthy controls. RESULTS: The intrathecal concentration of TNF-alpha was significantly increased in SVDpatients compared to healthy controls (p = 0.0001). The intrathecal levels of TNF-alpha were significantly correlated (r = 0.6, p = 0.02) to the levels of sulfatide, but not to the levels of neurofilament, (r = 0.08, NS). CONCLUSIONS: We have demonstrated intrathecal production of TNF-alpha in SVDpatients. The correlation between TNF-a and sulfatide levels in the CSF suggests that this apoptosis-inducing cytokine leads to the death of oligodendrocytes, thereby contributing to white matter degeneration, a hallmark of SVD. Copyright 2003 S. Karger AG, Basel
Authors: A L Jefferson; J M Massaro; P A Wolf; S Seshadri; R Au; R S Vasan; M G Larson; J B Meigs; J F Keaney; I Lipinska; S Kathiresan; E J Benjamin; C DeCarli Journal: Neurology Date: 2007-03-27 Impact factor: 9.910
Authors: A Wallin; E Kapaki; M Boban; S Engelborghs; D M Hermann; B Huisa; M Jonsson; M G Kramberger; L Lossi; B Malojcic; S Mehrabian; A Merighi; E B Mukaetova-Ladinska; G P Paraskevas; B O Popescu; R Ravid; L Traykov; G Tsivgoulis; G Weinstein; A Korczyn; M Bjerke; G Rosenberg Journal: BMC Neurol Date: 2017-05-23 Impact factor: 2.474
Authors: Deborah A Sival; Ursula Felderhoff-Müser; Thomas Schmitz; Eelco W Hoving; Carlo Schaller; Axel Heep Journal: Cerebrospinal Fluid Res Date: 2008-12-31