| Literature DB >> 12626688 |
Nancy L Urizar1, David D Moore.
Abstract
The resin of the Commiphora mukul tree has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments. Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which is an important regulator of cholesterol homeostasis. It is likely that this effect accounts for the hypolipidemic activity of these phytosteroids.Entities:
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Year: 2003 PMID： 12626688 DOI： 10.1146/annurev.nutr.23.011702.073102
Source DB: PubMed Journal: Annu Rev Nutr ISSN： 0199-9885 Impact factor: 11.848