Literature DB >> 12626647

GABAA receptor alpha 1 and beta 2 subunit null mutant mice: behavioral responses to ethanol.

Y A Blednov1, D Walker, H Alva, K Creech, G Findlay, R A Harris.   

Abstract

Mice lacking either the alpha1 or beta 2 subunit of the GABAA receptor were tested for ethanol, saccharin, or quinine consumption, ethanol-conditioned place preference, ethanol-conditioned taste aversion, ethanol-simulated motor activity, and handling-induced seizures following chronic consumption of an ethanol liquid diet. The alpha1 null mutants showed decreased ethanol and saccharin consumption, increased aversion to ethanol, and a marked stimulation of motor activity after injection of ethanol. The beta 2 null mutants showed decreased consumption of saccharin and quinine, but not ethanol. Surprisingly, neither mutant showed marked changes in handling induced seizures before or after withdrawal of ethanol. The unique effects of deletion of these two GABAA receptor subunits on ethanol responses are discussed in terms of the distinct changes in different populations of GABAA receptors.

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Year:  2003        PMID： 12626647     DOI： 10.1124/jpet.103.049478

Source DB:  PubMed          Journal:  J Pharmacol Exp Ther        ISSN： 0022-3565            Impact factor:   4.030


  45 in total

1.  Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data.

Authors:  Y A Blednov; R D Mayfield; J Belknap; R A Harris
Journal:  Genes Brain Behav       Date:  2012-04-06       Impact factor: 3.449

2.  Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.

Authors:  Y A Blednov; C M Borghese; M L McCracken; J M Benavidez; C R Geil; E Osterndorff-Kahanek; D F Werner; S Iyer; A Swihart; N L Harrison; G E Homanics; R A Harris
Journal:  J Pharmacol Exp Ther       Date:  2010-09-27       Impact factor: 4.030

3.  Reduced alcohol consumption in mice lacking preprodynorphin.

Authors:  Yuri A Blednov; Danielle Walker; Marni Martinez; R Adron Harris
Journal:  Alcohol       Date:  2006-10       Impact factor: 2.405

4.  Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors.

Authors:  Igor Ponomarev; Rajani Maiya; Mark T Harnett; Gwen L Schafer; Andrey E Ryabinin; Yuri A Blednov; Hitoshi Morikawa; Stephen L Boehm; Gregg E Homanics; Ari E Berman; Ari Berman; Kerrie H Lodowski; Susan E Bergeson; R Adron Harris
Journal:  J Neurosci       Date:  2006-05-24       Impact factor: 6.167

Review 5.  Genes and Alcohol Consumption: Studies with Mutant Mice.

Authors:  J Mayfield; M A Arends; R A Harris; Y A Blednov
Journal:  Int Rev Neurobiol       Date:  2016       Impact factor: 3.230

6.  Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.

Authors:  Y A Blednov; J M Benavidez; M Black; D Chandra; G E Homanics; U Rudolph; R A Harris
Journal:  Neuropharmacology       Date:  2012-11-09       Impact factor: 5.250

7.  Strain-specific programming of prenatal ethanol exposure across generations.

Authors:  Daniel O Popoola; Michael E Nizhnikov; Nicole M Cameron
Journal:  Alcohol       Date:  2017-01-04       Impact factor: 2.405

8.  Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol.

Authors:  Mridula Rewal; Rachel Jurd; T Michael Gill; Dao-Yao He; Dorit Ron; Patricia H Janak
Journal:  J Neurosci       Date:  2009-01-14       Impact factor: 6.167

Review 9.  GABA effects during neuronal differentiation of stem cells.

Authors:  Patricia Salazar; Marco A Velasco-Velázquez; Iván Velasco
Journal:  Neurochem Res       Date:  2008-03-21       Impact factor: 3.996

Review 10.  Ethanol drinking in rodents: is free-choice drinking related to the reinforcing effects of ethanol?

Authors:  Alexis S Green; Nicholas J Grahame
Journal:  Alcohol       Date:  2008-02       Impact factor: 2.405
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