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Literature DB >> 12626464

Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans.

Maaike de Fost¹, Rudy A Hartskeerl, Martijn R Groenendijk, Tom van der Poll.

Abstract

Heat-killed pathogenic Leptospira interrogans serovar rachmati induced the production of gamma interferon (IFN-gamma) and the IFN-gamma-inducing cytokines interleukin-12p40 (IL-12p40) and tumor necrosis factor alpha in human whole blood in vitro. The production of IFN-gamma was largely dependent on IL-12. These data establish that pathogenic leptospires can stimulate the production of type I cytokines involved in cellular immunity.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2003 PMID： 12626464 PMCID： PMC150539 DOI： 10.1128/cdli.10.2.332-335.2003

Source DB: PubMed Journal: Clin Diagn Lab Immunol ISSN： 1071-412X

18 in total

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10. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

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17 in total

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Journal: Ann Trop Med Parasitol Date: 2011-10

4. Identification of immunodominant B- and T-cell combined epitopes in outer membrane lipoproteins LipL32 and LipL21 of Leptospira interrogans.

Authors: Xu'ai Lin; Jinfang Zhao; Jing Qian; Yafei Mao; Jianping Pan; Liwei Li; Huiqin Peng; Yihui Luo; Jie Yan
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5. Lack of demonstrable memory T cell responses in humans who have spontaneously recovered from leptospirosis in the Peruvian Amazon.

Authors: Iskra Tuero; Joseph M Vinetz; Gary R Klimpel
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Journal: Clin Vaccine Immunol Date: 2015-10-21

7. Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-κB signaling pathways.

Authors: Huan Wang; Yifei Wu; David M Ojcius; X Frank Yang; Chenglin Zhang; Shibiao Ding; Xu'ai Lin; Jie Yan
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