Literature DB >> 12626333

Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep.

Katsumi Shimoda1, Kazunori Murakami, Perenlei Enkhbaatar, Lillian D Traber, Robert A Cox, Hal K Hawkins, Frank C Schmalstieg, Katalin Komjati, Jon G Mabley, Csaba Szabo, Andrew L Salzman, Daniel L Traber.   

Abstract

We investigated the role of the nuclear enzyme poly (ADP ribose) synthetase (PARS) in the pathogenesis of combined burn and smoke inhalation (burn/smoke) injury in an ovine model. Eighteen sheep were operatively prepared for chronic study. PARS inhibition was achieved by treatment with a novel and selective PARS inhibitor INO-1001. The PARS inhibitor attenuated 1) lung edema formation, 2) deterioration of gas exchange, 3) changes in airway blood flow, 4) changes in airway pressure, 5) lung histological injury, and 6) systemic vascular leakage. Lipid oxidation and plasma nitrite/nitrate (stable breakdown products of nitric oxide) levels were suppressed with the use of INO-1001. We conclude that PARS inhibition attenuates various aspects of the pathophysiological response in a clinically relevant experimental model of burn/smoke inhalation injury.

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Year:  2003        PMID： 12626333     DOI： 10.1152/ajplung.00319.2002

Source DB:  PubMed          Journal:  Am J Physiol Lung Cell Mol Physiol        ISSN： 1040-0605            Impact factor:   5.464


  32 in total

1.  Beneficial pulmonary effects of a metalloporphyrinic peroxynitrite decomposition catalyst in burn and smoke inhalation injury.

Authors:  Matthias Lange; Csaba Szabo; Perenlei Enkhbaatar; Rhykka Connelly; Eszter Horvath; Atsumori Hamahata; Robert A Cox; Aimalohi Esechie; Yoshimitsu Nakano; Lillian D Traber; David N Herndon; Daniel L Traber
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2010-11-12       Impact factor: 5.464

2.  Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.

Authors:  Pál Pacher; Lucas Liaudet; Jon G Mabley; Attila Cziráki; György Haskó; Csaba Szabó
Journal:  Int J Mol Med       Date:  2006-02       Impact factor: 4.101

3.  The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third-degree burn injury.

Authors:  Akbar Ahmad; Gabor Olah; David N Herndon; Csaba Szabo
Journal:  Br J Pharmacol       Date:  2017-03-05       Impact factor: 8.739

Review 4.  Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Authors:  Nathan A Berger; Valerie C Besson; A Hamid Boulares; Alexander Bürkle; Alberto Chiarugi; Robert S Clark; Nicola J Curtin; Salvatore Cuzzocrea; Ted M Dawson; Valina L Dawson; György Haskó; Lucas Liaudet; Flavio Moroni; Pál Pacher; Peter Radermacher; Andrew L Salzman; Solomon H Snyder; Francisco Garcia Soriano; Robert P Strosznajder; Balázs Sümegi; Raymond A Swanson; Csaba Szabo
Journal:  Br J Pharmacol       Date:  2017-03-26       Impact factor: 8.739

5.  Nebulization with γ-tocopherol ameliorates acute lung injury after burn and smoke inhalation in the ovine model.

Authors:  Yusuke Yamamoto; Perenlei Enkhbaatar; Linda E Sousse; Hiroyuki Sakurai; Sebastian W Rehberg; Sven Asmussen; Edward R Kraft; Charlotte L Wright; Eva Bartha; Robert A Cox; Hal K Hawkins; Lillian D Traber; Maret G Traber; Csaba Szabo; David N Herndon; Daniel L Traber
Journal:  Shock       Date:  2012-04       Impact factor: 3.454

6.  Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity.

Authors:  Dirk M Maybauer; Marc O Maybauer; Csaba Szabó; Martin Westphal; Lillian D Traber; Perenlei Enkhbaatar; Kanneganti G K Murthy; Yoshimitsu Nakano; Andrew L Salzman; David N Herndon; Daniel L Traber
Journal:  Biochem Biophys Res Commun       Date:  2008-10-23       Impact factor: 3.575

7.  Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury.

Authors:  Fiona D Saunders; Martin Westphal; Perenlei Enkhbaatar; Jianpu Wang; Konrad Pazdrak; Yoshimitsu Nakano; Atsumori Hamahata; Collette C Jonkam; Matthias Lange; Rhykka L Connelly; Gabriela A Kulp; Robert A Cox; Hal K Hawkins; Frank C Schmalstieg; Eszter Horvath; Csaba Szabo; Lillian D Traber; Elbert Whorton; David N Herndon; Daniel L Traber
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2009-12-04       Impact factor: 5.464

8.  Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injury.

Authors:  Perenlei Enkhbaatar; Rhykka Connelly; Jianpu Wang; Yoshimitsu Nakano; Matthias Lange; Atsumori Hamahata; Eszter Horvath; Csaba Szabo; Stefan Jaroch; Peter Hölscher; Margrit Hillmann; Lillian D Traber; Frank C Schmalstieg; David N Herndon; Daniel L Traber
Journal:  Crit Care Med       Date:  2009-01       Impact factor: 7.598

9.  Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model.

Authors:  Matthias Lange; Rhykka Connelly; Daniel L Traber; Atsumori Hamahata; Yoshimitsu Nakano; Aimalohi Esechie; Collette Jonkam; Sanna von Borzyskowski; Lillian D Traber; Frank C Schmalstieg; David N Herndon; Perenlei Enkhbaatar
Journal:  Crit Care       Date:  2010-07-05       Impact factor: 9.097

10.  Role of PARP on iNOS pathway during endotoxin-induced acute lung injury.

Authors:  Rainer Kiefmann; Kai Heckel; Martina Doerger; Sonja Schenkat; Christian Kupatt; Mechthild Stoeckelhuber; Józefa Wesierska-Gadek; Alwin E Goetz
Journal:  Intensive Care Med       Date:  2004-06-10       Impact factor: 17.440
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