Literature DB >> 12625701

Synthesis of 4-(5-iodo-3-methylpyrazolyl) phenylsulfonamide and its elaboration to a COX II inhibitor library by solution-phase suzuki coupling using Pd/C as a solid-supported catalyst.

Michael G Organ1, Stanislas Mayer.   

Abstract

An effective synthesis of 4-(5-iodo-3-methylpyrazolyl) phenylsulfonamide has been developed. This aromatic iodide template served as an efficient oxidative addition partner for the preparation of a solution-phase library of Celecoxib analogues via Suzuki coupling using Pd/C, a readily filterable catalyst.

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Year:  2003        PMID： 12625701     DOI： 10.1021/cc020045r

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


  4 in total

1.  Combining the use of solid-supported transition metal catalysis with microwave irradiation in solution-phase parallel library synthesis.

Authors:  Michael G Organ; Stanislas Mayer; Franck Lepifre; Blaise N'Zemba; Jayantilal Khatri
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

2.  A highly efficient microwave-assisted suzuki coupling reaction of aryl perfluorooctylsulfonates with boronic acids.

Authors:  Wei Zhang; Christine Hiu-Tung Chen; Yimin Lu; Tadamichi Nagashima
Journal:  Org Lett       Date:  2004-04-29       Impact factor: 6.005

3.  Approaches towards the synthesis of 5-aminopyrazoles.

Authors:  Ranjana Aggarwal; Vinod Kumar; Rajiv Kumar; Shiv P Singh
Journal:  Beilstein J Org Chem       Date:  2011-02-09       Impact factor: 2.883

4.  4-(3-Methyl-5-phenyl-1H-pyrazol-1-yl)benzene-sulfonamide.

Authors:  Abdullah M Asiri; Hassan M Faidallah; Abdulrahman O Al-Youbi; Salem A Basaif; Seik Weng Ng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-08-27
  4 in total

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