| Literature DB >> 12624728 |
Fanggeng Zou1, Yucheng Peng, Xiaoyan Wang, Aihua Sun, Wanqing Liu, Shaochum Bai, Hui Zhu, Bo Gao, Guoyin Feng, Lin He.
Abstract
The incidence of congenital preauricular fistula (CPF) is >1.1% in both Chinese and Caucasians, but it is even higher in Blacks. We mapped the locus for CPF to chromosome 8q11.1-q13.3 by linkage analysis of a family composed of 7 affected and 11 nonaffected members. The two-point LOD score was 2.40, shown by markers D8S285 and D8S1113 at a recombination fraction (theta) of 0.00. Results from three other markers (D8S1110, D8S260, and D8S1136) in the same region further support the linkage. Haplotype analysis for this family confined the locus to within an interval of approximately 26.7 cM, flanked by markers D8S532 and D8S279. A LOD score of <3 is likely due to the limitation of family size.Entities:
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Year: 2003 PMID： 12624728 DOI： 10.1007/s100380300024
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172