Literature DB >> 12622246

Synthesis and pharmacological evaluation of novel potential ultrashort-acting beta-blockers.

P Mokrý1, M Zemanová, J Csöllei, E Racanská, I Tumová.   

Abstract

The basic relationship between chemical structure and pharmacological activity of eight newly developed potential ultrashort-acting beta-adrenergic blockers was evaluated. The compounds studied are derivatives of arylcarbonyloxyaminopropanols and were prepared by four-step synthesis. All the compounds evaluated showed weak antiisoprenaline (beta-adrenergic receptor blocking) activity and antiarrhythmic (antiouabain) activity.

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Year:  2003        PMID： 12622246

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  2 in total

1.  Synthesis and biological evaluation of 2-hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(alkoxycarbonyl)amino]benzoates.

Authors:  Jan Tengler; Iva Kapustíková; Matúš Peško; Rodney Govender; Stanislava Keltošová; Petr Mokrý; Peter Kollár; Jim O'Mahony; Aidan Coffey; Katarína Král'ová; Josef Jampílek
Journal:  ScientificWorldJournal       Date:  2013-10-29

2.  Synthesis, Analysis, Cholinesterase-Inhibiting Activity and Molecular Modelling Studies of 3-(Dialkylamino)-2-hydroxypropyl 4-[(Alkoxy-carbonyl)amino]benzoates and Their Quaternary Ammonium Salts.

Authors:  Tereza Padrtova; Pavlina Marvanova; Klara Odehnalova; Renata Kubinova; Oscar Parravicini; Adriana Garro; Ricardo D Enriz; Otakar Humpa; Michal Oravec; Petr Mokry
Journal:  Molecules       Date:  2017-11-23       Impact factor: 4.411
  2 in total

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