Literature DB >> 12622200

Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice.

Maheep Bhatnagar1, Pratima Rao, Jain Sushma, Rekha Bhatnagar.   

Abstract

Light microscopic study of hippocampal sub-regions demonstrated significant number of degenerated nerve cell bodies in the CA3, CA4 and dentate gyrus(Dg) areas of sodium fluoride administered adult female mice. Ultrastructural studies revealed neurodegenrative characteristics like involution of cell membranes, swelling of mitochondria, clumping of chromatin material etc, can be observed in cell bodies of CA3, CA4 and dentate gyrus (Dg). Fluoride intoxicated animals also performed poorly in motor co-ordination tests and maze tests. Inability to perform well increased with higher fluoride concentration in drinking water.

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Year:  2002        PMID： 12622200

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN： 0019-5189            Impact factor:   0.818


  13 in total

1.  Autophagy May Be Involved in Fluoride-Induced Learning Impairment in Rats.

Authors:  Chengzhi Zhang; Simeng Huo; Yumei Fan; Yanhui Gao; Yanmei Yang; Dianjun Sun
Journal:  Biol Trace Elem Res       Date:  2019-05-20       Impact factor: 3.738

Review 2.  C. elegans as a model in developmental neurotoxicology.

Authors:  Joanna A Ruszkiewicz; Adi Pinkas; Mahfuzur R Miah; Rebecca L Weitz; Michael J A Lawes; Ayodele J Akinyemi; Omamuyovwi M Ijomone; Michael Aschner
Journal:  Toxicol Appl Pharmacol       Date:  2018-03-14       Impact factor: 4.219

3.  Fluoride-Induced Neuron Apoptosis and Expressions of Inflammatory Factors by Activating Microglia in Rat Brain.

Authors:  Nan Yan; Yan Liu; Shengnan Liu; Siqi Cao; Fei Wang; Zhengdong Wang; Shuhua Xi
Journal:  Mol Neurobiol       Date:  2015-08-08       Impact factor: 5.590

4.  A role of fluoride on free radical generation and oxidative stress in BV-2 microglia cells.

Authors:  Xi Shuhua; Liu Ziyou; Yan Ling; Wang Fei; Guifan Sun
Journal:  Mediators Inflamm       Date:  2012-08-13       Impact factor: 4.711

5.  JNK and NADPH oxidase involved in fluoride-induced oxidative stress in BV-2 microglia cells.

Authors:  Ling Yan; Shengnan Liu; Chen Wang; Fei Wang; Yingli Song; Nan Yan; Shuhua Xi; Ziyou Liu; Guifan Sun
Journal:  Mediators Inflamm       Date:  2013-08-29       Impact factor: 4.711

6.  Fluoride Alteration of [3H]Glucose Uptake in Wistar Rat Brain and Peripheral Tissues.

Authors:  Anna Rogalska; Katarzyna Kuter; Aleksandra Żelazko; Anna Głogowska-Gruszka; Elżbieta Świętochowska; Przemysław Nowak
Journal:  Neurotox Res       Date:  2017-02-27       Impact factor: 3.911

7.  Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence.

Authors:  Chhavi Sharma; Pooja Suhalka; Piyu Sukhwal; Neha Jaiswal; Maheep Bhatnagar
Journal:  Pharmacogn Mag       Date:  2014-01       Impact factor: 1.085

8.  Effects of Calcium on Drinking Fluorosis-induced Hippocampal Synaptic Plasticity Impairment in the Offspring of Rats.

Authors:  Zhang Zigu; Wang Xiaoyu; Nian Weiwei; Liao Qiuxia; Zhang Rui; Ouyang Wei
Journal:  Transl Neurosci       Date:  2017-12-29       Impact factor: 1.757

9.  Enteric innervation combined with proteomics for the evaluation of the effects of chronic fluoride exposure on the duodenum of rats.

Authors:  Carina Guimarães de Souza Melo; Juliana Vanessa Colombo Martins Perles; Jacqueline Nelisis Zanoni; Sara Raquel Garcia de Souza; Erika Xavier Santos; Aline de Lima Leite; Alessandro Domingues Heubel; Camila Oliveira E Souza; Juliana Gadelha de Souza; Marília Afonso Rabelo Buzalaf
Journal:  Sci Rep       Date:  2017-04-21       Impact factor: 4.379

Review 10.  Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: A possible role of fluoride and aluminum.

Authors:  Anna Strunecka; Russell L Blaylock; Jiri Patocka; Otakar Strunecky
Journal:  Surg Neurol Int       Date:  2018-04-09
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