Literature DB >> 12622139

A melanotic desmoplastic medulloblastoma: report of a rare case and review of the literature.

M C Sharma1, M Agarwal, A Suri, S Gaikwad, P Mukhopadhyay, C Sarkar.   

Abstract

A 28-year-old man had a desmoplastic medulloblastoma in the vermis and left cerebellum. This tumor was composed of nodular, reticulin-free zones (pale islands) surrounded by densely packed, highly proliferative cells that produced a dense intercellular reticulin network. Some of the cells were heavily pigmented, and this pigment proved to be melanin. Adult age, desmoplastic nature, and melanin pigmentation are some of the rare features of this tumor that need documentation. Further, this pigment was in the primitive cells, unlike in the published cases, in which it was present in the tubular or tubulopapillary component. To the best of our knowledge, this is the first published case of desmoplastic pigmented medulloblastoma, and the patient is the oldest reported to have this tumor.

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Year:  2002        PMID: 12622139     DOI: 10.1007/bf02478933

Source DB:  PubMed          Journal:  Brain Tumor Pathol        ISSN: 1433-7398            Impact factor:   3.298


  4 in total

Review 1.  Melanotic medulloblastoma in children.

Authors:  Wen-yan Li; Lu Ma; Jian Liu; Hua Yang; Qing Mao
Journal:  Childs Nerv Syst       Date:  2011-01-26       Impact factor: 1.475

Review 2.  Recent advances in embryonal tumours of the central nervous system.

Authors:  Chitra Sarkar; Prabal Deb; Mehar Chand Sharma
Journal:  Childs Nerv Syst       Date:  2005-01-29       Impact factor: 1.475

Review 3.  Medulloblastoma with melanotic differentiation: case report and review of the literature.

Authors:  Christine L Phillips; Lili Miles; Blaise V Jones; Mary Sutton; Kerry Crone; Maryam Fouladi
Journal:  J Neurooncol       Date:  2010-10-16       Impact factor: 4.130

4.  The role of immunohistochemistry in medullomyoblastoma--a case series highlighting divergent differentiation.

Authors:  Man Updesh S Sachdeva; Mahesha Vankalakunti; Aruna Rangan; Bishan D Radotra; Rajesh Chhabra; Rakesh K Vasishta
Journal:  Diagn Pathol       Date:  2008-04-25       Impact factor: 2.644

  4 in total

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