BACKGROUND: Cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy with mitomycin C for peritoneal carcinomatosis is used as a palliative treatment for a variety of malignancies. The purpose of this study was to measure the quality of life (QOL) of survivors (>3 years) after treatment. METHODS: Patients were interviewed by telephone with the following tools: (1) the Functional Assessment of Cancer Therapy-Colon (FACT-C), (2) the Short Form of the Medical Outcomes Study Questionnaire, (3) the Center for Epidemiologic Studies-Depression scale, (4) the Life Appreciation scale, (5) the Psychosocial Concerns Questionnaire, and (6) performance status rating. RESULTS: Seventeen (10 appendix, 5 large intestine, 1 ovarian, and 1 peritoneum) of 109 patients were interviewed from 3.1 to 8.0 years after treatment. Ten patients (62.5%) described their health as excellent or very good. No limitations on moderate activity were reported in 94% of cases. Paired t-tests were used to compare 10 patients who had baseline QOL data. FACT mean difference scores and P values (positive difference scores indicate improved QOL) were functional well-being: 4.9, P =.01; physical well-being: 3.3, P =.05; and FACT total: 14.3, P =.02. CONCLUSIONS: Long-term survival with good QOL is possible for selected patients with peritoneal carcinomatosis after cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy.
BACKGROUND: Cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy with mitomycin C for peritoneal carcinomatosis is used as a palliative treatment for a variety of malignancies. The purpose of this study was to measure the quality of life (QOL) of survivors (>3 years) after treatment. METHODS:Patients were interviewed by telephone with the following tools: (1) the Functional Assessment of Cancer Therapy-Colon (FACT-C), (2) the Short Form of the Medical Outcomes Study Questionnaire, (3) the Center for Epidemiologic Studies-Depression scale, (4) the Life Appreciation scale, (5) the Psychosocial Concerns Questionnaire, and (6) performance status rating. RESULTS: Seventeen (10 appendix, 5 large intestine, 1 ovarian, and 1 peritoneum) of 109 patients were interviewed from 3.1 to 8.0 years after treatment. Ten patients (62.5%) described their health as excellent or very good. No limitations on moderate activity were reported in 94% of cases. Paired t-tests were used to compare 10 patients who had baseline QOL data. FACT mean difference scores and P values (positive difference scores indicate improved QOL) were functional well-being: 4.9, P =.01; physical well-being: 3.3, P =.05; and FACT total: 14.3, P =.02. CONCLUSIONS: Long-term survival with good QOL is possible for selected patients with peritoneal carcinomatosis after cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy.
Authors: Franck Zenasni; Marion Botella; Dominique Elias; Sarah Dauchy; Valérie Boige; David Malka; Michel Ducreux; Jean-Pierre Pignon; Diane Goéré; Marc Pocard Journal: Support Care Cancer Date: 2009-02-06 Impact factor: 3.603
Authors: Rebecca M Dodson; Richard P McQuellon; Harveshp D Mogal; Katharine E Duckworth; Gregory B Russell; Konstantinos I Votanopoulos; Perry Shen; Edward A Levine Journal: Ann Surg Oncol Date: 2016-09-08 Impact factor: 5.344
Authors: Katharine E Duckworth; Richard P McQuellon; Gregory B Russell; Craig S Cashwell; Perry Shen; John H Stewart; Edward A Levine Journal: J Surg Oncol Date: 2012-03-22 Impact factor: 3.454
Authors: Ioannis T Konstantinidis; Christine Young; Vassiliki L Tsikitis; Ellyn Lee; Tun Jie; Evan S Ong Journal: World J Gastrointest Surg Date: 2012-06-27
Authors: Konstantinos I Votanopoulos; Katrina Swett; Aaron U Blackham; Chukwuemeka Ihemelandu; Perry Shen; John H Stewart; Edward A Levine Journal: Ann Surg Oncol Date: 2013-03-02 Impact factor: 5.344