Literature DB >> 12620652

CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA.

Luisa Bracci-Laudiero1, Domenico Celestino, Giuseppe Starace, Alessia Antonelli, Alessandro Lambiase, Annabella Procoli, Carlo Rumi, Marco Lai, Alessandra Picardi, Giovanna Ballatore, Sergio Bonini, Luigi Aloe.   

Abstract

In this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34(+) cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34(+) cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12620652     DOI： 10.1016/s0165-5728(03)00007-9

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  22 in total

1.  Ensheathing cell-conditioned medium directs the differentiation of human umbilical cord blood cells into aldynoglial phenotype cells.

Authors:  María Dolores Ponce-Regalado; Daniel Ortuño-Sahagún; Carlos Beas Zarate; Graciela Gudiño-Cabrera
Journal:  Hum Cell       Date:  2012-04-21       Impact factor: 4.174

2.  Human umbilical cord blood cells directly suppress ischemic oligodendrocyte cell death.

Authors:  A A Hall; A G Guyer; C C Leonardo; C T Ajmo; L A Collier; A E Willing; K R Pennypacker
Journal:  J Neurosci Res       Date:  2009-02       Impact factor: 4.164

3.  Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment.

Authors:  M Rihl; E Kruithof; C Barthel; F De Keyser; E M Veys; H Zeidler; D T Y Yu; J G Kuipers; D Baeten
Journal:  Ann Rheum Dis       Date:  2005-04-07       Impact factor: 19.103

4.  Cotransplantation with specific populations of spina bifida bone marrow stem/progenitor cells enhances urinary bladder regeneration.

Authors:  Arun K Sharma; Matthew I Bury; Natalie J Fuller; Andrew J Marks; David M Kollhoff; Manoj V Rao; Partha V Hota; Derek J Matoka; Seby L Edassery; Hatim Thaker; John F Sarwark; Joseph A Janicki; Guillermo A Ameer; Earl Y Cheng
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-19       Impact factor: 11.205

Review 5.  Neurotrophin Signaling and Stem Cells-Implications for Neurodegenerative Diseases and Stem Cell Therapy.

Authors:  Subrata Pramanik; Yanuar Alan Sulistio; Klaus Heese
Journal:  Mol Neurobiol       Date:  2016-11-05       Impact factor: 5.590

6.  Clonal immortalized human glial cell lines support varying levels of JC virus infection due to differences in cellular gene expression.

Authors:  Michael W Ferenczy; Kory R Johnson; Shannon M Steinberg; Leslie J Marshall; Maria Chiara Monaco; Alexander M Beschloss; Peter N Jensen; Eugene O Major
Journal:  J Neuroimmune Pharmacol       Date:  2013-09-20       Impact factor: 4.147

7.  Recombinant human nerve growth factor with a marked activity in vitro and in vivo.

Authors:  Anna M Colangelo; Nicoletta Finotti; Michela Ceriani; Lilia Alberghina; Enzo Martegani; Luigi Aloe; Laura Lenzi; Rita Levi-Montalcini
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-20       Impact factor: 11.205

8.  Human umbilical cord blood cells induce neuroprotective change in gene expression profile in neurons after ischemia through activation of Akt pathway.

Authors:  M D Shahaduzzaman; Vijay Mehta; Jason E Golden; Derrick D Rowe; Suzanne Green; Ramya Tadinada; Elspeth A Foran; Paul R Sanberg; Keith R Pennypacker; Alison E Willing
Journal:  Cell Transplant       Date:  2015-02-26       Impact factor: 4.064

9.  Mouse natural killer (NK) cells express the nerve growth factor receptor TrkA, which is dynamically regulated.

Authors:  Natacha Ralainirina; Nicolaas H C Brons; Wim Ammerlaan; Céline Hoffmann; François Hentges; Jacques Zimmer
Journal:  PLoS One       Date:  2010-12-01       Impact factor: 3.240

10.  Therapeutic benefit of intravenous administration of human umbilical cord blood- mononuclear cells following intracerebral hemorrhage in rat.

Authors:  Masoumeh Seghatoleslam; Mehdi Jalali; Mohammad Reza Nikravesh; Mahmoud Hosseini; Daryoush Hamidi Alamdari; Alireza Fazel
Journal:  Iran J Basic Med Sci       Date:  2012-05       Impact factor: 2.699
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.