Literature DB >> 12620405

Considering the cancer consequences of altered DNA polymerase function.

Thomas A Kunkel1.   

Abstract

Our appreciation of the DNA transactions that replicate and maintain a stable human genome is changing rapidly due to recent discoveries indicating that eukaryotic cells contain many more DNA polymerases than previously thought. This review describes emerging information on the properties and functions of human DNA polymerases, with emphasis on connections between DNA polymerase functions and cancer.

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Year:  2003        PMID： 12620405     DOI： 10.1016/s1535-6108(03)00027-8

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  17 in total

Review 1.  Infection, inflammation, and gastrointestinal cancer.

Authors:  C R Boland; M G Luciani; C Gasche; A Goel
Journal:  Gut       Date:  2005-09       Impact factor: 23.059

2.  Catalytic mechanism of human DNA polymerase lambda with Mg2+ and Mn2+ from ab initio quantum mechanical/molecular mechanical studies.

Authors:  G Andrés Cisneros; Lalith Perera; Miguel García-Díaz; Katarzyna Bebenek; Thomas A Kunkel; Lee G Pedersen
Journal:  DNA Repair (Amst)       Date:  2008-08-30

3.  Error-promoting DNA synthesis in ovarian cancer cells.

Authors:  Heqiao Dai; Robert J Hickey; Jianying Liu; Robert M Bigsby; Carita Lanner; Linda H Malkas
Journal:  Gynecol Oncol       Date:  2013-07-12       Impact factor: 5.482

4.  Somatic Mutations in Catalytic Core of POLK Reported in Prostate Cancer Alter Translesion DNA Synthesis.

Authors:  Santosh Yadav; Sudurkia Mukhopadhyay; Muralidharan Anbalagan; Nick Makridakis
Journal:  Hum Mutat       Date:  2015-06-25       Impact factor: 4.878

5.  DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.

Authors:  Fanny Lemée; Valérie Bergoglio; Anne Fernandez-Vidal; Alice Machado-Silva; Marie-Jeanne Pillaire; Anne Bieth; Catherine Gentil; Lee Baker; Anne-Laure Martin; Claire Leduc; Elena Lam; Eddy Magdeleine; Thomas Filleron; Naïma Oumouhou; Bernd Kaina; Mineaki Seki; Fanny Grimal; Magali Lacroix-Triki; Alastair Thompson; Henri Roché; Jean-Christophe Bourdon; Richard D Wood; Jean-Sébastien Hoffmann; Christophe Cazaux
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

6.  Roles of RAD6 epistasis group members in spontaneous polzeta-dependent translesion synthesis in Saccharomyces cerevisiae.

Authors:  Brenda K Minesinger; Sue Jinks-Robertson
Journal:  Genetics       Date:  2005-01-31       Impact factor: 4.562

Review 7.  Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes.

Authors:  Daniel Vlcek; Andrea Sevcovicová; Barbara Sviezená; Eliska Gálová; Eva Miadoková
Journal:  Curr Genet       Date:  2007-11-09       Impact factor: 3.886

8.  Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif.

Authors:  Nick M Makridakis; Lúcio Fábio Caldas Ferraz; Juergen K V Reichardt
Journal:  Hum Mutat       Date:  2009-01       Impact factor: 4.878

9.  DNA polymerase switching: effects on spontaneous mutagenesis in Escherichia coli.

Authors:  Elena Curti; John P McDonald; Samantha Mead; Roger Woodgate
Journal:  Mol Microbiol       Date:  2008-11-04       Impact factor: 3.501

10.  Characterization of a natural mutator variant of human DNA polymerase lambda which promotes chromosomal instability by compromising NHEJ.

Authors:  Gloria Terrados; Jean-Pascal Capp; Yvan Canitrot; Miguel García-Díaz; Katarzyna Bebenek; Tomas Kirchhoff; Alberto Villanueva; François Boudsocq; Valérie Bergoglio; Christophe Cazaux; Thomas A Kunkel; Jean-Sébastien Hoffmann; Luis Blanco
Journal:  PLoS One       Date:  2009-10-06       Impact factor: 3.240
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