Literature DB >> 1262027

A note on suxamethonium sensitivity and serum cholinesterase variants.

D P Agarwal, L M Srivastava, H W Goedde.   

Abstract

Sera from 21 cases of prolonged apnoea which showed normal phenotype (UU) on the basis of dibucaine and fluoride inhibition were re-examined by replacing the substrate benzoylcholine with succinylcholine (suxamethonium). 9 samples had normal enzyme activity but low dibucaine number (DN = less than 20) indicating the atypical variant; 6 sera showed no detectable enzyme activity. The remaining 6 samples had enzyme activity and DN comparable with healthy controls. The occurence of new variants of serum cholinesterase sensitive only to succinylcholine is suggested.

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Year:  1976        PMID： 1262027     DOI： 10.1007/BF00569981

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  15 in total

1.  STUDIES ON FORMAL GENETICS OF THE PSEUDO-CHOLINESTERASE POLYMORPHISM; AN ATYPICAL SEGREGATION IN A FAMILY.

Authors:  H W GOEDDE; W FUSS; D GEHRING; H BAITSCH
Journal:  Biochem Pharmacol       Date:  1964-04       Impact factor: 5.858

2.  The relation between plasma cholinesterase and prolonged apnea caused by succinylcholine.

Authors:  F F FOLDES; V M FOLDES; J C SMITH; E K ZSIGMOND
Journal:  Anesthesiology       Date:  1963 Mar-Apr       Impact factor: 7.892

3.  The hydrolysis of succinyldicholine by cholinesterase.

Authors:  V P WHITTAKER; S WIJESUNDERA
Journal:  Biochem J       Date:  1952-11       Impact factor: 3.857

Review 4.  [Pharmacogenetic problems in anesthesia].

Authors:  W Kalow
Journal:  Anaesthesist       Date:  1966-01       Impact factor: 1.041

5.  Evidence for different "silent genes" in the human serum pseudocholinesterase polymorphism.

Authors:  H W Goedde; K Altland
Journal:  Ann N Y Acad Sci       Date:  1968-06-14       Impact factor: 5.691

6.  New biochemical and immunological data on quantitative and qualitative variability of human pseudocholinesterase.

Authors:  K Altland; H W Goedde; K Held; M Jensen; H Münsch; E Solem
Journal:  Humangenetik       Date:  1971

7.  Suxamethonium sensitivity.

Authors:  H W Goedde; K Altland
Journal:  Ann N Y Acad Sci       Date:  1971-07-06       Impact factor: 5.691

8.  Heterogeneity in the silent gene phenotype of psudocholinesterase of human serum.

Authors:  K Altland; H W Goedde
Journal:  Biochem Genet       Date:  1970-04       Impact factor: 1.890

9.  A study of the pseudocholinesterase in 78 cases of apnoea following suxamethonium.

Authors:  J C Thompson; M Whittaker
Journal:  Acta Genet Stat Med       Date:  1966

10.  [Succinyldicholin sensitivity resulting from genetically determined serumcholinesterase variants].

Authors:  H W Goedde; H Münsch; H G Benkmann
Journal:  Prakt Anaesth       Date:  1976-10
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  3 in total

1.  Identification of a frameshift mutation responsible for the silent phenotype of human serum cholinesterase, Gly 117 (GGT----GGAG).

Authors:  C P Nogueira; M C McGuire; C Graeser; C F Bartels; M Arpagaus; A F Van der Spek; H Lightstone; O Lockridge; B N La Du
Journal:  Am J Hum Genet       Date:  1990-05       Impact factor: 11.025

Review 2.  Pharmacogenetics and ecogenetics.

Authors:  D P Agarwal; H W Goedde
Journal:  Experientia       Date:  1986-10-15

3.  Cholinesterase Newfoundland: a new succinylcholine-sensitive variant of cholinesterase at locus 1.

Authors:  N E Simpson; C R Elliott
Journal:  Am J Hum Genet       Date:  1981-05       Impact factor: 11.025
  3 in total

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