| Literature DB >> 12619167 |
Roberta La Starza1, Maurizio Trubia, Barbara Crescenzi, Caterina Matteucci, Massimo Negrini, Massimo F Martelli, Pier Giuseppe Pelicci, Cristina Mecucci.
Abstract
The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was involved in the translocation. At 12q13, the breakpoint fell within BAC 578A18, selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as the result of a reciprocal translocation, fuses with NUP98 in myeloid malignancies. Copyright 2003 Wiley-Liss, Inc.Entities:
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Year: 2003 PMID： 12619167 DOI： 10.1002/gcc.10182
Source DB: PubMed Journal: Genes Chromosomes Cancer ISSN： 1045-2257 Impact factor: 5.006