Literature DB >> 12618857

Genetic control of visceral leishmaniasis in a Sudanese population: candidate gene testing indicates a linkage to the NRAMP1 region.

B Bucheton1, L Abel, M M Kheir, A Mirgani, S H El-Safi, C Chevillard, A Dessein.   

Abstract

There is some evidence showing that genetic factors are involved in human susceptibility to parasitic diseases such as schistosomiasis and malaria. Studies have shown that the Nramp1 and H-2 genes are implicated in the control of Leishmania donovani infection in mice. We sought genetic loci involved in the control of susceptibility to visceral disease caused by L. donovani in humans. We studied 37 families with at least two affected sibs living in a village in eastern Sudan, where an outbreak of visceral leishmaniasis occurred between 1995 and 2000. The genetic markers located in five chromosomal regions containing candidate genes were typed: 2q35 (NRAMP1), 5q31-q33 (Th2 cytokine cluster), 6p21 (HLA/TNF-alpha), 6q23 (INFGRI) and 12q15 (INF-gamma). Linkage (multipoint lod-score=1.08; P=0.01) was observed for the 5'(CA) repeat polymorphism in the NRAMP1 promoter. This suggests that genetic variations of this gene affect susceptibility to visceral leishmaniasis in this population.

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Year:  2003        PMID： 12618857     DOI： 10.1038/sj.gene.6363927

Source DB:  PubMed          Journal:  Genes Immun        ISSN： 1466-4879            Impact factor:   2.676


  26 in total

1.  Association of the -183 polymorphism in the IFN-gamma gene promoter with hepatitis B virus infection in the Chinese population.

Authors:  Suxia Qi; Bangwei Cao; Mingwei Jiang; Changqing Xu; Yue Dai; Kun Li; Kun Wang; Yang Ke; Tao Ning
Journal:  J Clin Lab Anal       Date:  2005       Impact factor: 2.352

2.  Fine mapping of Leishmania major susceptibility Locus lmr2 and evidence of a role for Fli1 in disease and wound healing.

Authors:  Anuratha Sakthianandeswaren; Joan M Curtis; Colleen Elso; Beena Kumar; Tracey M Baldwin; Sash Lopaticki; Lukasz Kedzierski; Gordon K Smyth; Simon J Foote; Emanuela Handman
Journal:  Infect Immun       Date:  2010-04-05       Impact factor: 3.441

3.  Transmembrane molecules for phylogenetic analyses of pathogenic protists: Leishmania-specific informative sites in hydrophilic loops of trans- endoplasmic reticulum N-acetylglucosamine-1-phosphate transferase.

Authors:  Kayoko Waki; Sujoy Dutta; Debalina Ray; Bala Krishna Kolli; Leyla Akman; Shin-Ichiro Kawazu; Chung-Ping Lin; Kwang-Poo Chang
Journal:  Eukaryot Cell       Date:  2006-12-01

4.  Asymptomatic Leishmania infection: a new challenge for Leishmania control.

Authors:  Om Prakash Singh; Epco Hasker; David Sacks; Marleen Boelaert; Shyam Sundar
Journal:  Clin Infect Dis       Date:  2014-02-27       Impact factor: 9.079

5.  Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection.

Authors:  S M B Jeronimo; A K B Holst; S E Jamieson; R Francis; D R A Martins; F L Bezerra; N A Ettinger; E T Nascimento; G R Monteiro; H G Lacerda; E N Miller; H J Cordell; P Duggal; T H Beaty; J M Blackwell; M E Wilson
Journal:  Genes Immun       Date:  2007-08-23       Impact factor: 2.676

6.  A major susceptibility locus on chromosome 22q12 plays a critical role in the control of kala-azar.

Authors:  Bruno Bucheton; Laurent Abel; Sayda El-Safi; Musa M Kheir; Sylvana Pavek; Arnaud Lemainque; Alain J Dessein
Journal:  Am J Hum Genet       Date:  2003-10-13       Impact factor: 11.025

Review 7.  Genetics and visceral leishmaniasis: of mice and man.

Authors:  J M Blackwell; M Fakiola; M E Ibrahim; S E Jamieson; S B Jeronimo; E N Miller; A Mishra; H S Mohamed; C S Peacock; M Raju; S Sundar; M E Wilson
Journal:  Parasite Immunol       Date:  2009-05       Impact factor: 2.280

Review 8.  Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics.

Authors:  Giorgio Sirugo; Branwen J Hennig; Adebowale A Adeyemo; Alice Matimba; Melanie J Newport; Muntaser E Ibrahim; Kelli K Ryckman; Alessandra Tacconelli; Renato Mariani-Costantini; Giuseppe Novelli; Himla Soodyall; Charles N Rotimi; Raj S Ramesar; Sarah A Tishkoff; Scott M Williams
Journal:  Hum Genet       Date:  2008-05-30       Impact factor: 4.132

Review 9.  HLA and infectious diseases.

Authors:  Jenefer M Blackwell; Sarra E Jamieson; David Burgner
Journal:  Clin Microbiol Rev       Date:  2009-04       Impact factor: 26.132

10.  CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study.

Authors:  Léa Castellucci; Sarra E Jamieson; E Nancy Miller; Eliane Menezes; Joyce Oliveira; Andrea Magalhães; Luiz Henrique Guimarães; Marcus Lessa; Amélia Ribeiro de Jesus; Edgar M Carvalho; Jenefer M Blackwell
Journal:  BMC Med Genet       Date:  2010-01-20       Impact factor: 2.103
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