Literature DB >> 12618287

Analysis of a cluster of polymorphisms in AKT1 gene in bipolar pedigrees: a family-based association study.

Tomoko Toyota1, Kazuo Yamada, Sevilla D Detera-Wadleigh, Takeo Yoshikawa.   

Abstract

We have previously performed a genome scan in 22 multiplex pedigrees with bipolar disorder and detected a moderate linkage signal on distal portion of chromosome 14q22-32. One of the large pedigrees displayed a parametric lod score >3 at a marker on 14q23-32. Upon inspection of genes located in this region revealed AKT1, a kinase that activates a lithium-responsive cell-survival pathway. Because lithium is an effective mood stabilizer for bipolar disorder patients, AKT1 is an interesting candidate for further investigation. We screened the gene for possible mutations and detected 14 polymorphisms. Seven polymorphic sites were clustered in a small segment spanning exon 14 and downstream intron. Transmission of haplotypes constructed from this cluster showed a weak evidence of association between the AKT1 and bipolar disorder.

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Year:  2003        PMID： 12618287     DOI： 10.1016/s0304-3940(02)01428-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  13 in total

Review 1.  GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.

Authors:  Erik I Charych; Feng Liu; Stephen J Moss; Nicholas J Brandon
Journal:  Neuropharmacology       Date:  2009-07-23       Impact factor: 5.250

2.  MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.

Authors:  Albert H Kim; Mark Reimers; Brion Maher; Vernell Williamson; Omari McMichael; Joseph L McClay; Edwin J C G van den Oord; Brien P Riley; Kenneth S Kendler; Vladimir I Vladimirov
Journal:  Schizophr Res       Date:  2010-08-02       Impact factor: 4.939

Review 3.  A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health.

Authors:  Jean-Martin Beaulieu
Journal:  J Psychiatry Neurosci       Date:  2012-01       Impact factor: 6.186

4.  AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families.

Authors:  Dawn L Thiselton; Vladimir I Vladimirov; Po-Hsiu Kuo; Joseph McClay; Brandon Wormley; Ayman Fanous; Francis A O'Neill; Dermot Walsh; Edwin J C G Van den Oord; Kenneth S Kendler; Brien P Riley
Journal:  Biol Psychiatry       Date:  2007-09-06       Impact factor: 13.382

5.  Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins.

Authors:  Olli P H Pietiläinen; Tiina Paunio; Anu Loukola; Annamari Tuulio-Henriksson; Tuula Kieseppä; Paul Thompson; Arthur W Toga; Theo G M van Erp; Karri Silventoinen; Pia Soronen; William Hennah; Joni A Turunen; Juho Wedenoja; Outi M Palo; Kaisa Silander; Jouko Lönnqvist; Jaakko Kaprio; Tyrone D Cannon; Leena Peltonen
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2009-07-05       Impact factor: 3.568

6.  No Association Between AKT1 Polymorphisms and Methamphetamine Addiction in Iranian Population.

Authors:  Soudeh Ghafouri-Fard; Iman Azari; Fatemeh Hashemian; Azim Nejatizadeh; Mohammad Taheri
Journal:  J Mol Neurosci       Date:  2019-10-25       Impact factor: 3.444

7.  Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population.

Authors:  Kerang Zhang; Chunxia Yang; Yong Xu; Ning Sun; Hong Yang; Jinli Liu; Qi Xu; Yan Shen
Journal:  J Neural Transm (Vienna)       Date:  2009-12-24       Impact factor: 3.575

8.  Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling.

Authors:  A Gupta; T G Schulze; V Nagarajan; N Akula; W Corona; X-y Jiang; N Hunter; F J McMahon; S D Detera-Wadleigh
Journal:  Pharmacogenomics J       Date:  2011-03-08       Impact factor: 3.550

9.  Genetic Association between Akt1 Polymorphisms and Alzheimer's Disease in a Japanese Population.

Authors:  Nobuto Shibata; Tohru Ohnuma; Bolati Kuerban; Miwa Komatsu; Hajime Baba; Heii Arai
Journal:  Int J Alzheimers Dis       Date:  2011-07-14

10.  Association between AKT1 gene and Parkinson's disease: a protective haplotype.

Authors:  Georgia Xiromerisiou; Georgios M Hadjigeorgiou; Alexandros Papadimitriou; Evaggelos Katsarogiannis; Vasiliki Gourbali; Andrew B Singleton
Journal:  Neurosci Lett       Date:  2008-03-15       Impact factor: 3.046
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