| Literature DB >> 12617925 |
Tatsuya Shirahata1, Toshiaki Sunazuka, Kiminari Yoshida, Daisuke Yamamoto, Yoshihiko Harigaya, Takayuki Nagai, Hiroaki Kiyohara, Haruki Yamada, Isao Kuwajima, Satoshi Omura.
Abstract
Pinellic acid is a novel and potentially useful oral adjuvant when used in conjunction with intranasal inoculation of influenza HA vaccines. All stereoisomers of pinellic acid have been synthesized via regioselective asymmetric dihydroxylation, regioselective inversion, and stereoselective reduction, and their adjuvant activities were characterized. Among this series of isomers, 9S, 12S, 13S compound has the most potent adjuvant activity. Structure-activity relationships are discussed.Entities:
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Year: 2003 PMID： 12617925 DOI： 10.1016/s0960-894x(02)01069-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823