Literature DB >> 12617913

Synthesis and anticancer effect of chrysin derivatives.

Xing Zheng1, Wei-Dong Meng, Yang-Yan Xu, Jian-Guo Cao, Feng-Ling Qing.   

Abstract

A series of chrysin derivatives, prepared by alkylation, halogenation, nitration, methylation, acetylation and trifluoromethylation, were tested in vitro against human gastric adenocarcinoma cell line (SGC-7901) and colorectal adenocarcinoma (HT-29) cells. Among these derivatives of chrysin, 5,7-dimethoxy-8-iodochrysin 3 and 8-bromo-5-hydroxy-7-methoxychrysin 11 have the strongest activities against SGC-7901 and HT-29 cells, respectively. 5,7-Dihydroxy-8-nitrochrysin 12 were found to have strong activities against both SGC-7901 and HT-29 cells.

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Year:  2003        PMID： 12617913     DOI： 10.1016/s0960-894x(02)01081-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  22 in total

1.  A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases.

Authors:  Haidan Liu; Kangdong Liu; Zunnan Huang; Chan-Mi Park; N R Thimmegowda; Jae-Hyuk Jang; In-Ja Ryoo; Long He; Sun-Ok Kim; Naomi Oi; Ki Won Lee; Nak-Kyun Soung; Ann M Bode; Yifeng Yang; Xinmin Zhou; Raymond L Erikson; Jong-Seog Ahn; Joonsung Hwang; Kyoon Eon Kim; Zigang Dong; Bo-Yeon Kim
Journal:  J Biol Chem       Date:  2013-07-25       Impact factor: 5.157

2.  Role of oxidative stress in the antitumoral action of a new vanadyl(IV) complex with the flavonoid chrysin in two osteoblast cell lines: relationship with the radical scavenger activity.

Authors:  Luciana Naso; Evelina Gloria Ferrer; Luis Lezama; Teófilo Rojo; Susana Beatriz Etcheverry; Patricia Williams
Journal:  J Biol Inorg Chem       Date:  2010-04-04       Impact factor: 3.358

3.  Protective Effects of Chrysin Against Oxidative Stress and Inflammation Induced by Lead Acetate in Rat Kidneys: a Biochemical and Histopathological Approach.

Authors:  Sefa Kucukler; Fulya Benzer; Serkan Yildirim; Cihan Gur; Fatih Mehmet Kandemir; Aydin Sukru Bengu; Adnan Ayna; Cuneyt Caglayan; Muhammet Bahaeddin Dortbudak
Journal:  Biol Trace Elem Res       Date:  2020-06-29       Impact factor: 3.738

4.  8-bromo-7-methoxychrysin inhibits properties of liver cancer stem cells via downregulation of β-catenin.

Authors:  Mei-Fang Quan; Li-Hong Xiao; Zhi-Hong Liu; Hui Guo; Kai-Qun Ren; Fei Liu; Jian-Guo Cao; Xi-Yun Deng
Journal:  World J Gastroenterol       Date:  2013       Impact factor: 5.742

Review 5.  Apoptotic effects of chrysin in human cancer cell lines.

Authors:  Boon Yin Khoo; Siang Ling Chua; Prabha Balaram
Journal:  Int J Mol Sci       Date:  2010-05-19       Impact factor: 5.923

6.  Potential effects of chrysin on MDA-MB-231 cells.

Authors:  Teh Ban Hong; Anizah Rahumatullah; Thaneswary Yogarajah; Maimunah Ahmad; Khoo Boon Yin
Journal:  Int J Mol Sci       Date:  2010-03-11       Impact factor: 5.923

7.  7-difluoromethoxyl-5,4'-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1.

Authors:  Hong-Lin Xiang; Fei Liu; Mei-Fang Quan; Jian-Guo Cao; Yuan Lv
Journal:  World J Gastroenterol       Date:  2012-09-07       Impact factor: 5.742

8.  Induction of apoptosis of human gastric carcinoma SGC-7901 cell line by 5, 7-dihydroxy-8-nitrochrysin in vitro.

Authors:  Xiao-Hong Ai; Xing Zheng; Xiao-Qing Tang; Li Sun; Yang-Qin Zhang; Yong Qin; Hua-Qing Liu; Hong Xia; Jian-Guo Cao
Journal:  World J Gastroenterol       Date:  2007-07-28       Impact factor: 5.742

9.  A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1.

Authors:  Haidan Liu; Joonsung Hwang; Wei Li; Tae Woong Choi; Kangdong Liu; Zunnan Huang; Jae-Hyuk Jang; N R Thimmegowda; Ki Won Lee; In-Ja Ryoo; Jong-Seog Ahn; Ann M Bode; Xinmin Zhou; Yifeng Yang; Raymond L Erikson; Bo-Yeon Kim; Zigang Dong
Journal:  Cancer Prev Res (Phila)       Date:  2013-10-29

10.  Preventive effect of chrysin on bleomycin-induced lung fibrosis in rats.

Authors:  Talat Kilic; Osman Ciftci; Asli Cetin; Hasan Kahraman
Journal:  Inflammation       Date:  2014-12       Impact factor: 4.092
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