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Literature DB >> 12617911

Discovery of the first antibacterial small molecule inhibitors of MurB.

Joanne J Bronson¹, Kenneth L DenBleyker, Paul J Falk, Robert A Mate, Hsu-Tso Ho, Michael J Pucci, Lawrence B Snyder.

Abstract

A series of imidazolinone analogues was synthesized and shown to possess potent MurB inhibitory as well as good antibacterial activity.

Entities: Chemical

Mesh：

Substances：

Year: 2003 PMID： 12617911 DOI： 10.1016/s0960-894x(02)01076-4

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

12 in total

1. 3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.

Authors: Youjun Yang; Anatoly Severin; Rajiv Chopra; Girija Krishnamurthy; Guy Singh; William Hu; David Keeney; Kristine Svenson; Peter J Petersen; Pornpen Labthavikul; David M Shlaes; Beth A Rasmussen; Amedeo A Failli; Jay S Shumsky; Kristina M K Kutterer; Adam Gilbert; Tarek S Mansour
Journal: Antimicrob Agents Chemother Date: 2006-02 Impact factor: 5.191

Review 2. Resistance to antibiotics targeted to the bacterial cell wall.

Authors: I Nikolaidis; S Favini-Stabile; A Dessen
Journal: Protein Sci Date: 2014-01-17 Impact factor: 6.725

Review 3. Challenges of antibacterial discovery.

Authors: Lynn L Silver
Journal: Clin Microbiol Rev Date: 2011-01 Impact factor: 26.132

4. Synthesis of N-H Bearing Imidazolidinones and Dihydroimidazolones Using Aza-Heck Cyclizations.

Authors: Feiyang Xu; Scott A Shuler; Donald A Watson
Journal: Angew Chem Int Ed Engl Date: 2018-08-19 Impact factor: 15.336

Review 5. Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.

Authors: Gleiciane Leal Moraes; Guelber Cardoso Gomes; Paulo Robson Monteiro de Sousa; Cláudio Nahum Alves; Thavendran Govender; Hendrik G Kruger; Glenn E M Maguire; Gyanu Lamichhane; Jerônimo Lameira
Journal: Tuberculosis (Edinb) Date: 2015-01-29 Impact factor: 3.131

6. Evaluation of the metS and murB loci for antibiotic discovery using targeted antisense RNA expression analysis in Bacillus anthracis.

Authors: G C Kedar; Vickie Brown-Driver; Daniel R Reyes; Mark T Hilgers; Mark A Stidham; Karen Joy Shaw; John Finn; Robert J Haselbeck
Journal: Antimicrob Agents Chemother Date: 2007-03-05 Impact factor: 5.191

Discovery of the first antibacterial small molecule inhibitors of MurB.

1. 3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.

Review 2. Resistance to antibiotics targeted to the bacterial cell wall.

Review 3. Challenges of antibacterial discovery.

4. Synthesis of N-H Bearing Imidazolidinones and Dihydroimidazolones Using Aza-Heck Cyclizations.

Review 5. Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.

6. Evaluation of the metS and murB loci for antibiotic discovery using targeted antisense RNA expression analysis in Bacillus anthracis.

7. Cu(I)-catalyzed C-H alpha-amination of aryl ketones: direct synthesis of imidazolinones.

8. Cu(I)-catalyzed sequential diamination and dehydrogenation of terminal olefins: a facile approach to imidazolinones.

9. N-Amino-imidazolin-2-one peptide mimic synthesis and conformational analysis.

Review 10. Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen.