Literature DB >> 12617908

Synthesis of a new family of glycolipidic nitrones as potential antioxidant drugs for neurodegenerative disorders.

Grégory Durand1, Ange Polidori, Jean-Pierre Salles, Bernard Pucci.   

Abstract

This paper deals with the synthesis of a novel series of amphiphilic glycosylated spin-traps derived from alpha-Phenyl-N-tert-butyl nitrone (PBN) and an initial characterization of their anti-caspase-3 activity. Preliminary investigation of their anti-apoptosis effect showed they dramatically inhibit the activity of caspase-3 in cultured neuronal cells following induction of apoptosis by hydrogen peroxide.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12617908     DOI： 10.1016/s0960-894x(02)01079-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation.

Authors:  Amlan Das; Bhavani Gopalakrishnan; Lawrence J Druhan; Tse-Yao Wang; Francesco De Pascali; Antal Rockenbauer; Ira Racoma; Saradhadevi Varadharaj; Jay L Zweier; Arturo J Cardounel; Frederick A Villamena
Journal:  Br J Pharmacol       Date:  2014-05       Impact factor: 8.739

2.  The stability studies and in vitro hepatic microsomal metabolism of some alpha-phenyl-N-substituted nitrones in rats.

Authors:  Gülen Bulut; Mehmet Oktav; Mert Ulgen
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2004 Oct-Dec       Impact factor: 2.441

Review 3.  Melatonin, aging, and age-related diseases: perspectives for prevention, intervention, and therapy.

Authors:  Burkhard Poeggeler
Journal:  Endocrine       Date:  2005-07       Impact factor: 3.633

Review 4.  Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics.

Authors:  Frederick A Villamena; Amlan Das; Kevin M Nash
Journal:  Future Med Chem       Date:  2012-06       Impact factor: 3.808

Review 5.  Mechanisms of Mitochondrial Malfunction in Alzheimer's Disease: New Therapeutic Hope.

Authors:  Showkat Ul Nabi; Andleeb Khan; Ehraz Mehmood Siddiqui; Muneeb U Rehman; Saeed Alshahrani; Azher Arafah; Sidharth Mehan; Rana M Alsaffar; Athanasios Alexiou; Bairong Shen
Journal:  Oxid Med Cell Longev       Date:  2022-05-14       Impact factor: 7.310

6.  Lipophilic beta-cyclodextrin cyclic-nitrone conjugate: synthesis and spin trapping studies.

Authors:  Yongbin Han; Yangping Liu; Antal Rockenbauer; Jay L Zweier; Grégory Durand; Frederick A Villamena
Journal:  J Org Chem       Date:  2009-08-07       Impact factor: 4.354

7.  Spin trapping and cytoprotective properties of fluorinated amphiphilic carrier conjugates of cyclic versus linear nitrones.

Authors:  Grégory Durand; Robert A Prosak; Yongbin Han; Stéphanie Ortial; Antal Rockenbauer; Bernard Pucci; Frederick A Villamena
Journal:  Chem Res Toxicol       Date:  2009-09       Impact factor: 3.739

8.  Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling.

Authors:  Amlan Das; Bhavani Gopalakrishnan; Oliver H Voss; Andrea I Doseff; Frederick A Villamena
Journal:  Biochem Pharmacol       Date:  2012-05-10       Impact factor: 5.858

9.  Facile one-pot synthesis of novel N-benzimidazolyl-α-arylnitrones catalyzed by salts of transition metals.

Authors:  Mehdi Kalhor; Sima Samiei; S Ahmad Mirshokraei
Journal:  RSC Adv       Date:  2019-12-17       Impact factor: 4.036

Review 10.  Neuroprotection by radical avoidance: search for suitable agents.

Authors:  Rüdiger Hardeland
Journal:  Molecules       Date:  2009-12-07       Impact factor: 4.411
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.