Literature DB >> 12617902

Hydroporphyrins as tumour photosensitizers: synthesis and photophysical studies of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin.

Yann Ferrand1, Ludovic Bourré, Gérard Simonneaux, Sonia Thibaut, Fabrice Odobel, Y Lajat, Thierry Patrice.   

Abstract

The synthesis and characterization of 2,3-dihydro-5,15-di(3,5-dihydroxyphenyl) porphyrin is reported. The phototoxicity on C6 cell lines and the pharmacokinetics are also reported as preliminary results showing a very high tumor to skin ratio and short retention time in tissues, and thus promising activity in photodynamic therapy.

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Year:  2003        PMID： 12617902     DOI： 10.1016/s0960-894x(03)00002-7

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Structural Characterization, Photophysics, and Biological Evaluation.

Authors:  Mafalda Laranjo; Nelson A M Pereira; Andreia S R Oliveira; Márcia Campos Aguiar; Gonçalo Brites; Bruno F O Nascimento; Beatriz Serambeque; Bruna D P Costa; João Pina; J Sérgio Seixas de Melo; Marta Pineiro; M Filomena Botelho; Teresa M V D Pinho E Melo
Journal:  Front Chem       Date:  2022-04-27       Impact factor: 5.545

2.  Sparsely substituted chlorins as core constructs in chlorophyll analogue chemistry. I. Synthesis.

Authors:  Marcin Ptaszek; Brian E McDowell; Masahiko Taniguchi; Han-Je Kim; Jonathan S Lindsey
Journal:  Tetrahedron       Date:  2007-04-30       Impact factor: 2.457

3.  Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.

Authors:  Leanne B Josefsen; Ross W Boyle
Journal:  Theranostics       Date:  2012-10-04       Impact factor: 11.556
  3 in total

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