Literature DB >> 12617475

New chemical syntheses of cholest-4,6-dien-3-one.

Edward J Parish1, Hang Sun, Ding Lu, Stephen A Kizito, Zhihai Qiu.   

Abstract

Steroidal dienones represent a significant class of compounds that are useful intermediates in the further functionalization of the steroid nucleus. Their chemical synthesis can be problematic owing to the lack of a simplified method of preparation and the occurrence of impurities that can be difficult to remove. We have endeavored to develop new methods of chemical synthesis of cholest-4,6-dien-3-one that would yield a product of high purity.

Entities:  

Mesh:

Substances:

Year:  2002        PMID: 12617475     DOI: 10.1007/s11745-002-1021-0

Source DB:  PubMed          Journal:  Lipids        ISSN: 0024-4201            Impact factor:   1.880


  7 in total

1.  The scope and mechanism of the reaction of dinitrophenylhydrazine with steroidal bromo ketones.

Authors:  C DJERASSI
Journal:  J Am Chem Soc       Date:  1949-03       Impact factor: 15.419

2.  Antiprogestational agents. The synthesis of 7-alkyl steroidal ketones with anti-implantational and antidecidual activity.

Authors:  J F Grunwell; H D Benson; J O Johnston; V Petrow
Journal:  Steroids       Date:  1976-06       Impact factor: 2.668

3.  Novel steroidal pure antiestrogens.

Authors:  J Bowler; T J Lilley; J D Pittam; A E Wakeling
Journal:  Steroids       Date:  1989-07       Impact factor: 2.668

4.  Synthesis and biochemical evaluation of inhibitors of estrogen biosynthesis.

Authors:  R W Brueggemeier; E E Floyd; R E Counsell
Journal:  J Med Chem       Date:  1978-10       Impact factor: 7.446

5.  A synthesis of 7 alpha-substituted estradiols: synthesis and biological evaluation of a 7 alpha-pentyl-substituted BODIPY fluorescent conjugate and a fluorine-18-labeled 7 alpha-pentylestradiol analog.

Authors:  A N French; S R Wilson; M J Welch; J A Katzenellenbogen
Journal:  Steroids       Date:  1993-04       Impact factor: 2.668

6.  Synthesis of fluorescent 4,6,8(14)-trien-3-one steroids via 3,5,7-trien-3-ol ethers. Important probes for steroid-protein interactions.

Authors:  R M Böhme; M A Kempfle
Journal:  Steroids       Date:  1994-04       Impact factor: 2.668

7.  7 alpha-Alkyltestosterone derivatives: synthesis and activity as androgens and as aromatase inhibitors.

Authors:  A J Solo; C Caroli; M V Darby; T McKay; W D Slaunwhite; P Hebborn
Journal:  Steroids       Date:  1982-12       Impact factor: 2.668

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.