Literature DB >> 12617308

The neurite-stimulating influence of components of medicinal leech salivary gland secretions in organotypic culture of spinal ganglia.

N I Chalisova1, I P Baskova, L L Zavalova, V A Pennijainen.   

Abstract

The effects of components from medicinal leech (Hirudo medicinalis) salivary gland secretions and the therapeutic agent Piyavit on the growth of chick embryo neurites in organotypic culture were studied. Native destabilase and bdellin A at concentrations of 0.01, 0.02, 0.05, and 0.1 ng/ml, bdellin B at a concentration of 0.05 ng/ml, and eglin at a concentration of 0.1 ng/ml had neurite-stimulating activity, evident on the third day of organotypic culture of spinal ganglia. The stimulatory activity of destabilase was lost after revere-phase chromatography. The neurite-stimulating activity of the extract of the therapeutic agent Piyavit (200 ng/ml) in organotypic ganglion culture appeared to result from the neurite-stimulating salivary gland components within this agent, suggesting that Piyavit could be used for the treatment of neurodegenerative disorders.

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Year:  2003        PMID： 12617308     DOI： 10.1023/a:1021187500632

Source DB:  PubMed          Journal:  Neurosci Behav Physiol        ISSN： 0097-0549


  10 in total

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7.  Genes from the medicinal leech (Hirudo medicinalis) coding for unusual enzymes that specifically cleave endo-epsilon (gamma-Glu)-Lys isopeptide bonds and help to dissolve blood clots.

Authors:  L Zavalova; S Lukyanov; I Baskova; E Snezhkov; S Akopov; S Berezhnoy; E Bogdanova; E Barsova; E D Sverdlov
Journal:  Mol Gen Genet       Date:  1996-11-27

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Authors:  Y A Barde; D Edgar; H Thoenen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

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Journal:  Biokhimiia       Date:  1985-03

Review 10.  Proteinase inhibitors from the European medicinal leech Hirudo medicinalis: structural, functional and biomedical aspects.

Authors:  P Ascenzi; G Amiconi; W Bode; M Bolognesi; M Coletta; E Menegatti
Journal:  Mol Aspects Med       Date:  1995
  10 in total

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