BACKGROUND: The determination of progression from afterload mismatch to myocardial failure in small animals requires invasive monitoring to assess ventricular pressure. OBJECTIVE: We sought to (1) validate the noninvasive determination of blood pressure using optical plethysmography, and (2) determine the time course and progression from afterload mismatch to myocyte failure in neonatal rabbits with coarctation (aortic banding at 7-10 days of life) compared to normal rabbits. METHODS AND RESULTS: Comparison of continuous arterial pressure determined by optical plethysmography with high-fidelity intraarterial recording was performed in nine animals. An accuracy of 5.9 +/- 4.7 and 9.2 +/- 6.9 mm Hg for systolic and diastolic blood pressure was noted. Fourier analysis confirmed similar frequency components. Simultaneous transthoracic echocardiography and optical plethysmography were serially performed in 33 banded and 13 control animals. Load-dependent and -independent measures of myocardial function were obtained. Midwall contractility, initially normal, showed a gradual significant deterioration (0.22 +/- 1.68 [week 3] to -1.36 +/- 1.24 [week 6]; Z-scores). CONCLUSIONS: This novel noninvasive method for determination of myocardial mechanics allows for serial evaluation of cardiac function and the determination of the time course from compensated hypertrophy to myocyte failure.
BACKGROUND: The determination of progression from afterload mismatch to myocardial failure in small animals requires invasive monitoring to assess ventricular pressure. OBJECTIVE: We sought to (1) validate the noninvasive determination of blood pressure using optical plethysmography, and (2) determine the time course and progression from afterload mismatch to myocyte failure in neonatal rabbits with coarctation (aortic banding at 7-10 days of life) compared to normal rabbits. METHODS AND RESULTS: Comparison of continuous arterial pressure determined by optical plethysmography with high-fidelity intraarterial recording was performed in nine animals. An accuracy of 5.9 +/- 4.7 and 9.2 +/- 6.9 mm Hg for systolic and diastolic blood pressure was noted. Fourier analysis confirmed similar frequency components. Simultaneous transthoracic echocardiography and optical plethysmography were serially performed in 33 banded and 13 control animals. Load-dependent and -independent measures of myocardial function were obtained. Midwall contractility, initially normal, showed a gradual significant deterioration (0.22 +/- 1.68 [week 3] to -1.36 +/- 1.24 [week 6]; Z-scores). CONCLUSIONS: This novel noninvasive method for determination of myocardial mechanics allows for serial evaluation of cardiac function and the determination of the time course from compensated hypertrophy to myocyte failure.
Authors: Ingeborg Friehs; Douglas B Cowan; Yeong-Hoon Choi; Kendra M Black; Reanne Barnett; Manoj K Bhasin; Christian Daly; Simon J Dillon; Towia A Libermann; Francis X McGowan; Pedro J del Nido; Sidney Levitsky; James D McCully Journal: Am J Physiol Heart Circ Physiol Date: 2012-12-21 Impact factor: 4.733
Authors: Ingeborg Friehs; Rodrigo Barillas; Nikolay V Vasilyev; Nathalie Roy; Francis X McGowan; Pedro J del Nido Journal: Circulation Date: 2006-07-04 Impact factor: 29.690
Authors: Ingeborg Friehs; Hung Cao-Danh; Meena Nathan; Francis X McGowan; Pedro J del Nido Journal: Biochem Biophys Res Commun Date: 2005-05-27 Impact factor: 3.575
Authors: Elisabeth Kaza; Klemens Ablasser; Dimitrios Poutias; Eric R Griffiths; Fawzy A Saad; Jochen G Hofstaetter; Pedro J del Nido; Ingeborg Friehs Journal: Cardiovasc Res Date: 2010-10-08 Impact factor: 10.787
Authors: Rodrigo Barillas; Ingeborg Friehs; Hung Cao-Danh; Joseph F Martinez; Pedro J del Nido Journal: Ann Thorac Surg Date: 2007-07 Impact factor: 4.330
Authors: Andriana Nikolova; Klemens Ablasser; Moritz C Wyler von Ballmoos; Dimitrios Poutias; Elisabeth Kaza; Francis X McGowan; Marsha A Moses; Pedro J Del Nido; Ingeborg Friehs Journal: Ann Thorac Surg Date: 2012-07-12 Impact factor: 4.330
Authors: Eric R Griffiths; Ingeborg Friehs; Elisabeth Scherr; Dimitrios Poutias; Francis X McGowan; Pedro J Del Nido Journal: J Thorac Cardiovasc Surg Date: 2009-12-28 Impact factor: 5.209